Planta Med 2019; 85(18): 1476
DOI: 10.1055/s-0039-3399866
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Chemical constituents and cytotoxic activity from Xylaria spp. fungi

P Noppawan
1   Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
,
N Suwannasai
2   Department of Biology, Faculty of Science, Srinakharinwirot University,, Bangkok, 10110, Thailand
,
W Mongkolthanaruk
3   Department of Microbiology, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
,
T Senawong
4   Department of Biochemistry, Faculty of Science, Khon Kaen University,, Khon Kaen 40002, Thailand
,
U Prawat
5   Department of Chemistry, Faculty of Science and Technology, Phuket Rajabhat University,, Phuket 83000, Thailand
,
P Moontragoon
6   Department of Physics, Faculty of Science, Khon Kaen University,, Khon Kaen 40002, Thailand
,
J Boonmak
7   Materials Chemistry Research Center, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
,
S Youmgme
7   Materials Chemistry Research Center, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
,
S McCloskey
1   Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University,, Khon Kaen, 40002, Thailand
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

Also available at
 

Cancer is by far a leading cause of human deaths worldwide and as such there is an ongoing search for drugs that can halt it, cure it or prevent it from happening. [1]. More than two-thirds of the marked chemotherapeutic agents are based on natural products [2]. However, only a few of the identified anti-cancer natural product candidates entered the drug development process, hence the search for potential candidates is still essential. Xylaria, one of the wood-decaying fungi genus belonging to Xylariaceae family, has been shown to be a potential source of diverse secondary metabolites, especially cytotoxic compounds [3]. Thus, this research aimed to help in this search for new effective anti-cancer drug candidates from this genus found in Thailand.

Three selected Xylaria spp., namely X. allantoidea SWUF76; X. spp. SWUF08-37 and SWUF15-05 were studied, from which eleven (1-11), thirteen (12-24) and twelve (25-36) compounds were isolated, respectively. Their structures were determined based on NMR, MS, ECD and X-ray data. The isolated compounds were evaluated for cytotoxic activities against cancer cell lines and normal Vero cell lines by MTT assay. Compound 7 showed substantial cytotoxicity against HeLa (IC50 = 2.24 µg/mL), HT29 (IC50 = 2.51 µg/mL), HCT116 (IC50 = 3.50 µg/mL) and MCF-7 (IC50 = 3.77 µg/mL) cells. Compound 23 showed reasonable cytotoxicity and compounds 12 and 13 showed slight cytotoxicity against all tested cell lines.

These results show that the selected Xylaria spp. produced diverse secondary metabolites, some of which exhibited cytotoxic activities against various cancer cell lines.

Zoom Image
Fig. 1 Cytotoxic compounds from selected Xylaria spp.
 

  • References

  • 1 Dogan N, Dogan I. Global patterns of incline and mortality in lung cancer. EJMO 2019; 3: 28-32
    PubMedGoogle Scholar
  • 2 Cragg GM, Pezzuto JM. Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. Med Princ Pract 2016; 25: 41-59
    CrossrefPubMedGoogle Scholar
  • 3 Mecías-Rubalcava ML, Sánchez-Fernández RE. Secondary metabolites of endophytic Xylaria species with potential applications in medicine and agriculture. World J Microbiol Biotechnol 2017; 33: 15-36
    CrossrefPubMedGoogle Scholar