Planta Med 2019; 85(18): 1482
DOI: 10.1055/s-0039-3399880
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Protective effects of ethanol extract of a Mexican propolis on indomethacin-induced gastric mucosal damage in mice.

DV Pilar
1   UNAM FES Iztacala,, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala Tlalnepantla, Estado de México, C.P. 54090
,
VVS Ibran
1   UNAM FES Iztacala,, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala Tlalnepantla, Estado de México, C.P. 54090
,
RC Mario
2   IPN Escuela Nacional de Ciencias Biológicas,, Avenida Wilfrido Massieu C.P. 07360 Zacatenco, Distrito Federal, México
,
CA Octavio
2   IPN Escuela Nacional de Ciencias Biológicas,, Avenida Wilfrido Massieu C.P. 07360 Zacatenco, Distrito Federal, México
,
MM Canales-Martinez
1   UNAM FES Iztacala,, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala Tlalnepantla, Estado de México, C.P. 54090
,
RMM Aurelio
1   UNAM FES Iztacala,, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala Tlalnepantla, Estado de México, C.P. 54090
,
MA Rodriguez-Monroy
1   UNAM FES Iztacala,, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala Tlalnepantla, Estado de México, C.P. 54090
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

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Peptic ulcer is a lesion in the gastric mucosa. Current treatments exhibit limited efficacy and several side effects, which makes it necessary to search for new alternatives[1]. One of these alternatives can be propolis. This natural product contains mainly phenols and flavonoids, which are directly related to its antioxidant, antimicrobial and anti-inflammatory activities[2]. The aim of this project was to evaluate the gastroprotective effect of the ethanolic extract of Mexicali propolis (EeMeP) in a model of indomethacin-induced gastric ulceration in mice.

Gastric lesions were induced by intragastric administration of indomethacin at a dose of 20 mg/Kg[3]. Treatment with EeMeP (100, 200 and 300 mg/Kg) was administered 2 hours before indomethacin.

The results show that the EeMeP contains chrysin, kaempferol, luteolin, pinocembrin, quercetin, baicalein, apigenin and myricetin, as well as a high free-radical scavenging capacity (89.92 μg/mL) which is related to the concentration of phenols (28.66 %) and flavonoids (6.02%). EeMeP showed aniinflammatory and antimicrobial activity. Group treated with EeMeP presented a reduction in the percentage of lesion area, attenuation of histological damage and maintenance of the mucus barrier, which can be translated as a protection of the gastric tissue compared with the group without treatment. In the group treated with EeMeP, the activity of MPO, and the levels of TNF-α, IL-1β and IL-6, decreased significantly. In the same group, an increase in the activity of GPx and SOD was observed.

We show that EeMeP has a gastroprotective effect and that this effect can be attributed to its flavonoid content.

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Fig. 1
 

  • References

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