Planta Med 2019; 85(18): 1498
DOI: 10.1055/s-0039-3399922
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Phenolic constituents isolated from the flower of Carex kobomugi

N Abe
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, Gifu 501-1196, JAPAN
,
S Ayabe
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, Gifu 501-1196, JAPAN
,
M Haba
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, Gifu 501-1196, JAPAN
,
T Tanaka
2   Laboratory of Natural Resources, Gifu Pharmaceutical University,, 1–25–4 Daigaku-nishi, Gifu, Gifu 501-1196, JAPAN
,
M Oyama
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, Gifu 501-1196, JAPAN
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Publikationsdatum:
20. Dezember 2019 (online)

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Cyperaceae is the family of flowering plants known as sage. This family comprises about 5000 species defined in about 70 genera. These species are widely distributed throughout the world and are found growing in low to high land. The genus Carex consists of approximately 1500 species distributed throughout the world. Previously, many chemical constituents have been isolated from the family Cyperaceae including sesquiterpenes [1] (genus Cyperus), stilbenes [2] (genus Carex), diterpenes [3] (genus Killinga), and acetophenones [4] (genus Schoenus). Carex kobomugi, a perennial plant, widely grows in the coastal zones in Japan. Some stilbene oligomers have been reported from this plant root. These oligomers are of interest due to the inconsistent isomers that result from the resveratrol framework. While C. kobomugi have been shown to possess several interesting metabolites, no reports have yet been published that describe the chemical constituents found in flowers. Herein, we report the isolation and the structural elucidation of several compounds. Fresh flowers of C. kobomugi (3.1 kg) were extracted with methanol (3 × 5L) at room temperature. The combined extracts were concentrated under reduced pressure to provide 182 g of a dark extract, part of which (172 g) was suspended in H2O and successively extracted with EtOAc and n-BuOH. The EtOAc soluble fraction was chromatographed/purified on silica gel, Sephadex LH-20, Sep-pak C18 cartridge, and preparative HPLC. All compounds were isolated from the EtOAc fraction by repeated column chromatography as noted above. We report the isolation of five new phenolics along with seven known compounds.

 

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