Planta Med 2019; 85(18): 1546
DOI: 10.1055/s-0039-3400084
Main Congress Poster
Poster Session 2
© Georg Thieme Verlag KG Stuttgart · New York

Sauromatum venosum – an anti-proliferative plant from the Himalayas

M Khalil-ur-Rehman
1   Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz,, Universitaetsplatz 4, 8010 Graz, Austria
,
EM Pferschy-Wenzig
1   Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz,, Universitaetsplatz 4, 8010 Graz, Austria
,
N Kretschmer
1   Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz,, Universitaetsplatz 4, 8010 Graz, Austria
,
R Bauer
1   Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz,, Universitaetsplatz 4, 8010 Graz, Austria
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

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Cancer is an important cause of morbidity and mortality worldwide with 18.1 million new cases and 9.1 million deaths in 2018 [1]. Natural products are the leading source of anticancer drugs as 93 drugs from natural sources are among the 174 drugs approved for the treatment of cancer since 1980 [2]. At the foothills of the Himalayas, the local people living in Pakistan part of the Jummu and Kashmir use Sauromatum venosum (Dryand. ex Aiton) Kunth (family Araceae, for the treatment of cancer [3].

The aim of this study is to elucidate the active constituents of Sauromatum venosum possessing anticancer activity. For this, the plant extracts (n-hexane, dichloromethane and methanol) and isolated fractions from active extracts were tested against different cancer cell lines using a cell metabolic rate estimation assay. Dichloromethane and n-hexane extracts of tubers of the plant showed marked activity against both adherent and non-adherent cancer cell lines (MDA-MB-231 and CCRF-CEM). To identify the constituents responsible for this activity, column chromatographic fractions were subjected to LC-DAD-MS and LC-HRMS analyses for dereplication. The analyses revealed that tubers contain lignans, predominantly lariciresinol and pinoresinol. These lignans showed moderate activity against the cancer cell lines compared to the crude extracts. Therefore, isolation and structure elucidation of further active compounds is in progress.

 

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