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J Pediatr Intensive Care 2020; 09(02): 081-086
DOI: 10.1055/s-0039-3400466
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Human Rhinovirus/Enterovirus in Pediatric Acute Respiratory Distress Syndrome

Michele E. Smith
1   Department of Pediatrics, Columbia University Medical Center, New York-Presbyterian Children's Hospital, New York, United States
,
Patrick T. Wilson 
1   Department of Pediatrics, Columbia University Medical Center, New York-Presbyterian Children's Hospital, New York, United States
› Author Affiliations Funding None.
Further Information

Publication History

16 September 2019

12 October 2019

Publication Date:
21 November 2019 (online)

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Abstract

The role of human rhinovirus/enterovirus (HRV/HEV) in severe lower respiratory tract infections remains unclear. We characterized the respiratory status of children admitted to a large academic pediatric intensive care unit (PICU) who tested positive for only HRV/HEV. One hundred and fifty-five children met inclusion criteria with 62% requiring positive pressure respiratory support of 5 cm of water pressure or more within the first 24 hours of admission. Among them, 34% had SaO2 to FiO2 ratios of 264 or less with 22 patients (14%) meeting criteria for pediatric acute respiratory distress syndrome. HRV/HEV is associated with significant respiratory disease in children admitted to the PICU.

Keywords

rhinovirus - enterovirus - pediatric intensive care units - pediatric acute respiratory distress syndrome
 

  • References

  • 1 Stott EJ, Heath GF. Factors affecting the growth of Rhinovirus 2 in suspension cultures of L132 cells. J Gen Virol 1970; 6 (01) 15-24
    CrossrefPubMedGoogle Scholar
  • 2 Tyrrell DA, Parsons R. Some virus isolations from common colds. III. Cytopathic effects in tissue cultures. Lancet 1960; 1 (7118): 239-242
    PubMedGoogle Scholar
  • 3 Winther B, Brofeldt S, Christensen B, Mygind N. Light and scanning electron microscopy of nasal biopsy material from patients with naturally acquired common colds. Acta Otolaryngol 1984; 97 (3,4): 309-318
    CrossrefPubMedGoogle Scholar
  • 4 Papadopoulos NG, Sanderson G, Hunter J, Johnston SL. Rhinoviruses replicate effectively at lower airway temperatures. J Med Virol 1999; 58 (01) 100-104
    CrossrefPubMedGoogle Scholar
  • 5 Papadopoulos NG, Bates PJ, Bardin PG. , et al. Rhinoviruses infect the lower airways. J Infect Dis 2000; 181 (06) 1875-1884
    CrossrefPubMedGoogle Scholar
  • 6 Gutman JA, Peck AJ, Kuypers J, Boeckh M. Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases. Bone Marrow Transplant 2007; 40 (08) 809-811
    CrossrefPubMedGoogle Scholar
  • 7 Ishizuka S, Yamaya M, Suzuki T. , et al. Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. J Infect Dis 2003; 188 (12) 1928-1939
    CrossrefPubMedGoogle Scholar
  • 8 Passariello C, Schippa S, Conti C. , et al. Rhinoviruses promote internalisation of Staphylococcus aureus into non-fully permissive cultured pneumocytes. Microbes Infect 2006; 8 (03) 758-766
    CrossrefPubMedGoogle Scholar
  • 9 El-Sahly HM, Atmar RL, Glezen WP, Greenberg SB. Spectrum of clinical illness in hospitalized patients with “common cold” virus infections. Clin Infect Dis 2000; 31 (01) 96-100
    CrossrefPubMedGoogle Scholar
  • 10 Miller EK, Lu X, Erdman DD. , et al; New Vaccine Surveillance Network. Rhinovirus-associated hospitalizations in young children. J Infect Dis 2007; 195 (06) 773-781
    CrossrefPubMedGoogle Scholar
  • 11 McMillan JA, Weiner LB, Higgins AM, Macknight K. Rhinovirus infection associated with serious illness among pediatric patients. Pediatr Infect Dis J 1993; 12 (04) 321-325
    CrossrefPubMedGoogle Scholar
  • 12 Krilov L, Pierik L, Keller E. , et al. The association of rhinoviruses with lower respiratory tract disease in hospitalized patients. J Med Virol 1986; 19 (04) 345-352
    CrossrefPubMedGoogle Scholar
  • 13 Kim JO, Hodinka RL. Serious respiratory illness associated with rhinovirus infection in a pediatric population. Clin Diagn Virol 1998; 10 (01) 57-65
    CrossrefPubMedGoogle Scholar
  • 14 Johnston SL, Sanderson G, Pattemore PK. , et al. Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol 1993; 31 (01) 111-117
    CrossrefPubMedGoogle Scholar
  • 15 Nokso-Koivisto J, Kinnari TJ, Lindahl P, Hovi T, Pitkäranta A. Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms. J Med Virol 2002; 66 (03) 417-420
    CrossrefPubMedGoogle Scholar
  • 16 Rakes GP, Arruda E, Ingram JM. , et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med 1999; 159 (03) 785-790
    CrossrefPubMedGoogle Scholar
  • 17 Jartti T, Lehtinen P, Vuorinen T, Koskenvuo M, Ruuskanen O. Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children. J Med Virol 2004; 72 (04) 695-699
    CrossrefPubMedGoogle Scholar
  • 18 Poritz MA, Blaschke AJ, Byington CL. , et al. FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection. PLoS One 2011; 6 (10) e26047
    CrossrefPubMedGoogle Scholar
  • 19 Pediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med 2015; 16 (05) 428-439
    CrossrefPubMedGoogle Scholar
  • 20 Spaeder MC, Custer JW, Miles AH. , et al. A multicenter outcomes analysis of children with severe rhino/enteroviral respiratory infection. Pediatr Crit Care Med 2015; 16 (02) 119-123
    Google Scholar
  • 21 Bernard GR, Artigas A, Brigham KL. , et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149 (3, Pt 1): 818-824
    CrossrefPubMedGoogle Scholar
  • 22 Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glodé MP, Dominguez SR. Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses. J Clin Virol 2013; 56 (01) 41-45
    CrossrefPubMedGoogle Scholar
  • 23 Iwane MK, Prill MM, Lu X. , et al. Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis 2011; 204 (11) 1702-1710
    CrossrefPubMedGoogle Scholar
  • 24 Rudi JM, Molina F, Díaz R. , et al. The role of rhinovirus in children hospitalized for acute respiratory disease, Santa Fe, Argentina. J Med Virol 2015; 87 (12) 2027-2032
    CrossrefPubMedGoogle Scholar
  • 25 Louie JK, Roy-Burman A, Guardia-Labar L. , et al. Rhinovirus associated with severe lower respiratory tract infections in children. Pediatr Infect Dis J 2009; 28 (04) 337-339
    CrossrefPubMedGoogle Scholar
  • 26 Lambert SB, Allen KM, Druce JD. , et al. Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens. Pediatrics 2007; 120 (04) e929-e937
    CrossrefPubMedGoogle Scholar
  • 27 Johnston SL, Pattemore PK, Sanderson G. , et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995; 310 (6989): 1225-1229
    CrossrefPubMedGoogle Scholar
  • 28 Goldstein B, Giroir B, Randolph A. ; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6 (01) 2-8
    CrossrefPubMedGoogle Scholar
  • 29 Ceylan G, İşgüder R, Ahu Kara A, Gülfidan G, Ağın H, Devrim İ. Acute respiratory distress syndrome caused by rhinovirus. Journal of Pediatric Infection 2017; 11: E84-E87
    CrossrefPubMedGoogle Scholar
  • 30 Soni P, Rai A, Aggarwal N, Kamholz S, Yoon T, Kupfer Y. Enterovirus/human rhinovirus: a rare cause of acute respiratory distress syndrome. Crit Care Med 2016; 44: 523
    PubMedGoogle Scholar
  • 31 Dalal P, Varma D. Enterovirus-rhinovirus pneumonia leading to acute respiratory distress syndrome (ARDS) requiring mechanical ventilation in a nonimmunocompromised healthy adult. Chest 2012; 142: 341A
    CrossrefPubMedGoogle Scholar