The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis

Mandar Kulkarni; Katherine N. Slain; Alexandre T. Rotta; Steven L. Shein

doi:10.1055/s-0039-3400467

Journal of Pediatric Intensive Care, Table of Contents

J Pediatr Intensive Care 2020; 09(02): 087-091
DOI: 10.1055/s-0039-3400467

Original Article

Georg Thieme Verlag KG Stuttgart · New York

The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis

Mandar Kulkarni

¹Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

,

Katherine N. Slain

¹Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

²Department of Pediatrics, Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States

,

Alexandre T. Rotta

³Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States

⁴Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke Children's Hospital and Health Center, Durham, North Carolina, United States

,

Steven L. Shein

¹Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

²Department of Pediatrics, Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States

› Author Affiliations

Abstract

Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6.25 [interquartile range: 5.01–7.92] vs. 6.06 [4.73–7.54], p = 0.48), but was associated with expected changes in fluid balance and urine output. Secondary analysis suggested more favorable effects of furosemide in children with worse baseline OSI. The reported common use of furosemide by pediatric intensivists obligates further study to better establish its efficacy, or lack thereof, in mechanically ventilated children.

Keywords

bronchiolitis - mechanical ventilation - diuretics

Full Text

References

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