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DOI: 10.1055/s-0039-3401466
Indian Subcontinent’s First Bilateral Supracondylar Level Upper Limb Transplantation
Publication History
Received: 16 July 2019
Accepted after revision: 14 October 2019
Publication Date:
26 December 2019 (online)
Abstract
Introduction This is the first case of supracondylar level transplant from the Indian subcontinent, performed for a bilateral below elbow amputee. It has a completely different set of challenges for the transplant team, with a relatively shorter ischemia time window.
The technical considerations for the same have been discussed in detail in this article.
Materials and Methods The patient was a 19-year-old female who lost her both upper limbs at proximal forearm level due to severe crush injury following a road traffic accident. Insufficient bone length on either side necessitated a supracondylar level transplant. The preoperative workup included detailed clinical evaluation, biochemical, and psychological evaluation.
The donor was a young brain-dead, male patient from a hospital, 30 minutes away. The donor and recipient preparations in this case were unique. The recipient’s own elbow flexors and extensors were used while the elbow joint was from the donor. The specific challenges we faced during this procedure have been described in detail.
Results The transplantation has been a complete technical success, with the patient rehabilitated back to her independent life style. This article describes only the technical considerations. The functional recovery aspect is part of an another soon to be published manuscript.
Conclusion Supracondylar level arm-transplant requires a highly coordinated team effort with precise preoperative planning, along with meticulous attention to detail to achieve a successful outcome. In properly selected patients, it could be a life-changing procedure, worth all the effort.
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References
- 1 Siemionow MZ, Kulahci Y, Bozkurt M. Composite tissue allotransplantation. Plast Reconstr Surg 2009; 124 (6, Suppl): e327-e339
- 2 Shores JT, Higgins JP, Lee WP. Above-elbow (supracondylar) arm transplantation: clinical considerations and surgical technique. Tech Hand Up Extrem Surg 2013; 17 (04) 221-227
- 3 Petruzzo P, Dubernard JM. The International Registry on Hand and Composite Tissue allotransplantation. Clin Transpl 2011; •••: 247-253
- 4 Murphy BD, Zuker RM, Borschel GH. Vascularized composite allotransplantation: an update on medical and surgical progress and remaining challenges. J Plast Reconstr Aesthet Surg 2013; 66 (11) 1449-1455
- 5 Jones NF, Schneeberger S. Arm transplantation: prospects and visions. Transplant Proc 2009; 41 (02) 476-480
- 6 Messner F, Grahammer J, Hautz T, Brandacher G, Schneeberger S. Ischemia/reperfusion injury in vascularized tissue allotransplantation: tissue damage and clinical relevance. Curr Opin Organ Transplant 2016; 21 (05) 503-509
- 7 Tuffs A. Munich surgeons perform world’s first transplantation of whole arms. BMJ 2008; 337: a1162
- 8 Iglesias M, Salazar-Hernandez F. et al. Anatomical and microsurgical implications in total and midarm transplantation. J Reconstr Microsurg Open 2017; 2: e94-e102
- 9 Cavadas PC, Ibáñez J, Thione A, Alfaro L. Bilateral trans-humeral arm transplantation: result at 2 years. Am J Transplant 2011; 11 (05) 1085-1090
- 10 Jablecki J, Kaczmarzyk L, Domanasiewicz A. et al. Result of arm-level upper-limb transplantation in two recipients at 19- and 30-month follow-up. Ann Transplant 2012; 17 (03) 126-132
- 11 Chhabra A, Ahlawat S, Belzberg A, Andreseik G. Peripheral nerve injury grading simplified on MR neurography: as referenced to Seddon and Sunderland classifications. Indian J Radiol Imaging 2014; 24 (03) 217-224
- 12 Datta D, Selvarajah K, Davey N. Functional outcome of patients with proximal upper limb deficiency–acquired and congenital. Clin Rehabil 2004; 18 (02) 172-177
- 13 Amadio PC. Outcome assessment in hand surgery and hand therapy: an update. J Hand Ther 2001; 14 (02) 63-67
- 14 Gorantla VS, Brandacher G, Schneeberger S. et al. Favoring the risk-benefit balance for upper extremity transplantation–the Pittsburgh Protocol. Hand Clin 2011; 27 (04) 511-520, ix–x
- 15 Hartzell TL, Benhaim P, Imbriglia JE. et al. Surgical and technical aspects of hand transplantation: is it just another replant?. Hand Clin 2011; 27 (04) 521-530, x
- 16 Weiss T. [Mechanisms of action of prostaglandin E1 in therapy of peripheral arterial occlusive diseases]. Vasa 2003; 32 (04) 187-192