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DOI: 10.1055/s-0039-3402015
Emergent Transjugular Intrahepatic Portosystemic Shunt Creation in Acute Variceal Bleeding
Publication History
Publication Date:
04 March 2020 (online)
Abstract
Emergent transjugular intrahepatic portosystemic shunt (TIPS) creation is most commonly employed in the setting of acute variceal hemorrhage. Given a propensity for decompensation, these patients often require a multidisciplinary, multimodal approach involving prompt diagnosis, pharmacologic therapy, and endoscopic intervention. While successful in the majority of cases, failure to medically control initial bleeding can prompt interventional radiology consultation for emergent portal decompression via TIPS creation. This article discusses TIPS creation in emergent, acute variceal hemorrhage, reviewing the natural history of gastroesophageal varices, presentation and diagnosis of acute variceal hemorrhage, pharmacologic therapy, endoscopic approaches, patient selection and risk stratification for TIPS, technical considerations for TIPS creation, adjunctive embolotherapy, and the role of salvage TIPS versus early TIPS in acute variceal hemorrhage.
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References
- 1 Mallet M, Rudler M, Thabut D. Variceal bleeding in cirrhotic patients. Gastroenterol Rep (Oxf) 2017; 5 (03) 185-192
- 2 Nadim MK, Durand F, Kellum JA. , et al. Management of the critically ill patient with cirrhosis: a multidisciplinary perspective. J Hepatol 2016; 64 (03) 717-735
- 3 Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology 2017; 65 (01) 310-335
- 4 Zanetto A, Garcia-Tsao G. Management of acute variceal hemorrhage. F1000 Res 2019; 8: 8
- 5 Groszmann RJ, Garcia-Tsao G, Bosch J. , et al; Portal Hypertension Collaborative Group. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005; 353 (21) 2254-2261
- 6 de Franchis R, Pascal JP, Ancona E. , et al. Definitions, methodology and therapeutic strategies in portal hypertension. A Consensus Development Workshop, Baveno, Lake Maggiore, Italy, April 5 and 6, 1990. J Hepatol 1992; 15 (1-2): 256-261
- 7 Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. ; Practice Guidelines Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46 (03) 922-938
- 8 Abby Philips C, Sahney A. Oesophageal and gastric varices: historical aspects, classification and grading: everything in one place. Gastroenterol Rep (Oxf) 2016; 4 (03) 186-195
- 9 Kovalak M, Lake J, Mattek N, Eisen G, Lieberman D, Zaman A. Endoscopic screening for varices in cirrhotic patients: data from a national endoscopic database. Gastrointest Endosc 2007; 65 (01) 82-88
- 10 Christensen E, Fauerholdt L, Schlichting P, Juhl E, Poulsen H, Tygstrup N. Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone. Gastroenterology 1981; 81 (05) 944-952
- 11 Merli M, Nicolini G, Angeloni S. , et al. Incidence and natural history of small esophageal varices in cirrhotic patients. J Hepatol 2003; 38 (03) 266-272
- 12 Gulamhusein AF, Kamath PS. The epidemiology and pathogenesis of gastrointestinal varices. Tech Gastrointest Endosc 2017; 19 (02) 62-68
- 13 Watanabe K, Kimura K, Matsutani S, Ohto M, Okuda K. Portal hemodynamics in patients with gastric varices. A study in 230 patients with esophageal and/or gastric varices using portal vein catheterization. Gastroenterology 1988; 95 (02) 434-440
- 14 Chao Y, Lin HC, Lee FY. , et al. Hepatic hemodynamic features in patients with esophageal or gastric varices. J Hepatol 1993; 19 (01) 85-89
- 15 Merkel C, Marin R, Angeli P. , et al; Gruppo Triveneto per l'Ipertensione Portale. A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterology 2004; 127 (02) 476-484
- 16 D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22 (01) 332-354
- 17 Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 1992; 16 (06) 1343-1349
- 18 Kim T, Shijo H, Kokawa H. , et al. Risk factors for hemorrhage from gastric fundal varices. Hepatology 1997; 25 (02) 307-312
- 19 Dagradi AE. The natural history of esophageal varices in patients with alcoholic liver cirrhosis. An endoscopic and clinical study. Am J Gastroenterol 1972; 57 (06) 520-540
- 20 Barbu LA, Mărgăritescu ND, Şurlin MV. Diagnosis and treatment algorithms of acute variceal bleeding. Curr Health Sci J 2017; 43 (03) 191-200
- 21 Rudler M, Rousseau G, Benosman H. , et al. Peptic ulcer bleeding in patients with or without cirrhosis: different diseases but the same prognosis?. Aliment Pharmacol Ther 2012; 36 (02) 166-172
- 22 Merkel C, Zoli M, Siringo S. , et al. Prognostic indicators of risk for first variceal bleeding in cirrhosis: a multicenter study in 711 patients to validate and improve the North Italian Endoscopic Club (NIEC) index. Am J Gastroenterol 2000; 95 (10) 2915-2920
- 23 Tripathi D, Therapondos G, Jackson E, Redhead DN, Hayes PC. The role of the transjugular intrahepatic portosystemic stent shunt (TIPSS) in the management of bleeding gastric varices: clinical and haemodynamic correlations. Gut 2002; 51 (02) 270-274
- 24 Morrison JD, Mendoza-Elias N, Lipnik AJ. , et al. Gastric varices bleed at lower portosystemic pressure gradients than esophageal varices. J Vasc Interv Radiol 2018; 29 (05) 636-641
- 25 de Franchis R. ; Baveno VI Faculty. Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension. J Hepatol 2015; 63 (03) 743-752
- 26 Tayyem O, Bilal M, Samuel R, Merwat SK. Evaluation and management of variceal bleeding. Dis Mon 2018; 64 (07) 312-320
- 27 Bosch J, García-Pagán JC. Prevention of variceal rebleeding. Lancet 2003; 361 (9361): 952-954
- 28 D'Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: an evidence-based approach. Semin Liver Dis 1999; 19 (04) 475-505
- 29 Gluud LL, Krag A. Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults. Cochrane Database Syst Rev 2012; (08) CD004544
- 30 Mishra SR, Chander Sharma B, Kumar A, Sarin SK. Endoscopic cyanoacrylate injection versus beta-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial. Gut 2010; 59 (06) 729-735
- 31 Seo YS. Prevention and management of gastroesophageal varices. Clin Mol Hepatol 2018; 24 (01) 20-42
- 32 Tandon P, Bishay K, Fisher S. , et al. Comparison of clinical outcomes between variceal and non-variceal gastrointestinal bleeding in patients with cirrhosis. J Gastroenterol Hepatol 2018; 33 (10) 1773-1779
- 33 Hsu YC, Lin JT, Chen TT, Wu MS, Wu CY. Long-term risk of recurrent peptic ulcer bleeding in patients with liver cirrhosis: a 10-year nationwide cohort study. Hepatology 2012; 56 (02) 698-705
- 34 Storace M, Martin JG, Shah J, Bercu Z. CTA as an adjuvant tool for acute intra-abdominal or gastrointestinal bleeding. Tech Vasc Interv Radiol 2017; 20 (04) 248-257
- 35 Trikudanathan G, Israel J, Cappa J, O'Sullivan DM. Association between proton pump inhibitors and spontaneous bacterial peritonitis in cirrhotic patients - a systematic review and meta-analysis. Int J Clin Pract 2011; 65 (06) 674-678
- 36 de Franchis R, Dell'Era A. Invasive and noninvasive methods to diagnose portal hypertension and esophageal varices. Clin Liver Dis 2014; 18 (02) 293-302
- 37 Koch DG, Arguedas MR, Fallon MB. Risk of aspiration pneumonia in suspected variceal hemorrhage: the value of prophylactic endotracheal intubation prior to endoscopy. Dig Dis Sci 2007; 52 (09) 2225-2228
- 38 Dellinger RP, Levy MM, Carlet JM. , et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36 (01) 296-327
- 39 Dellinger RP, Levy MM, Rhodes A. , et al; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39 (02) 165-228
- 40 Rossaint R, Bouillon B, Cerny V. , et al; Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010; 14 (02) R52
- 41 Rossaint R, Bouillon B, Cerny V. , et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 2016; 20: 100
- 42 Kravetz D, Sikuler E, Groszmann RJ. Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution. Gastroenterology 1986; 90 (5, Pt 1): 1232-1240
- 43 Kravetz D, Bosch J, Arderiu M, Pilar Pizcueta M, Rodés J. Hemodynamic effects of blood volume restitution following a hemorrhage in rats with portal hypertension due to cirrhosis of the liver: influence of the extent of portal-systemic shunting. Hepatology 1989; 9 (06) 808-814
- 44 Villanueva C, Colomo A, Bosch A. , et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013; 368 (01) 11-21
- 45 Bosch J, Thabut D, Bendtsen F. , et al; European Study Group on rFVIIa in UGI Haemorrhage. Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial. Gastroenterology 2004; 127 (04) 1123-1130
- 46 Bosch J, Thabut D, Albillos A. , et al; International Study Group on rFVIIa in UGI Hemorrhage. Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: a randomized, controlled trial. Hepatology 2008; 47 (05) 1604-1614
- 47 de Franchis R, Arcidiacono PG, Carpinelli L. , et al. Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: a multicenter, double-blind study. New Italian Endoscopic Club. Hepatology 1993; 18 (05) 1102-1107
- 48 European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol 2018; 69 (02) 406-460
- 49 Wells M, Chande N, Adams P. , et al. Meta-analysis: vasoactive medications for the management of acute variceal bleeds. Aliment Pharmacol Ther 2012; 35 (11) 1267-1278
- 50 Bernard B, Grangé JD, Khac EN, Amiot X, Opolon P, Poynard T. Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 1999; 29 (06) 1655-1661
- 51 Bernard B, Cadranel JF, Valla D, Escolano S, Jarlier V, Opolon P. Prognostic significance of bacterial infection in bleeding cirrhotic patients: a prospective study. Gastroenterology 1995; 108 (06) 1828-1834
- 52 Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila F. , et al. Meta-analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding - an updated Cochrane review. Aliment Pharmacol Ther 2011; 34 (05) 509-518
- 53 Fernández J, Ruiz del Arbol L, Gómez C. , et al. Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology 2006; 131 (04) 1049-1056 , quiz 1285
- 54 Villanueva C, Piqueras M, Aracil C. , et al. A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding. J Hepatol 2006; 45 (04) 560-567
- 55 Dai C, Liu WX, Jiang M, Sun MJ. Endoscopic variceal ligation compared with endoscopic injection sclerotherapy for treatment of esophageal variceal hemorrhage: a meta-analysis. World J Gastroenterol 2015; 21 (08) 2534-2541
- 56 Hsu YC, Chung CS, Tseng CH. , et al. Delayed endoscopy as a risk factor for in-hospital mortality in cirrhotic patients with acute variceal hemorrhage. J Gastroenterol Hepatol 2009; 24 (07) 1294-1299
- 57 Chen PH, Chen WC, Hou MC. , et al. Delayed endoscopy increases re-bleeding and mortality in patients with hematemesis and active esophageal variceal bleeding: a cohort study. J Hepatol 2012; 57 (06) 1207-1213
- 58 Cheung J, Soo I, Bastiampillai R, Zhu Q, Ma M. Urgent vs. non-urgent endoscopy in stable acute variceal bleeding. Am J Gastroenterol 2009; 104 (05) 1125-1129
- 59 Yoo JJ, Chang Y, Cho EJ. , et al. Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding. World J Gastroenterol 2018; 24 (44) 5025-5033
- 60 Hernández-Gea V, Procopet B, Giráldez Á. , et al; International Variceal Bleeding Observational Study Group and Baveno Cooperation. Preemptive-TIPS improves outcome in high-risk variceal bleeding: an observational study. Hepatology 2019; 69 (01) 282-293
- 61 Ríos Castellanos E, Seron P, Gisbert JP, Bonfill Cosp X. Endoscopic injection of cyanoacrylate glue versus other endoscopic procedures for acute bleeding gastric varices in people with portal hypertension. Cochrane Database Syst Rev 2015; (05) CD010180
- 62 Loffroy R, Estivalet L, Cherblanc V. , et al. Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage. World J Gastroenterol 2013; 19 (37) 6131-6143
- 63 Tapper EB, Beste L, Curry M, Bonder A, Waljee A, Saini S. Suboptimal implementation of evidence-based therapy for acute variceal hemorrhage: a systematic review of observational studies. Clin Gastroenterol Hepatol 2017; 15 (09) 1373-1381.e7
- 64 Nadler J, Stankovic N, Uber A. , et al. Outcomes in variceal hemorrhage following the use of a balloon tamponade device. Am J Emerg Med 2017; 35 (10) 1500-1502
- 65 Shao XD, Qi XS, Guo XZ. Esophageal stent for refractory variceal bleeding: a systemic review and meta-analysis. BioMed Res Int 2016; 2016: 4054513
- 66 Escorsell À, Pavel O, Cárdenas A. , et al; Variceal Bleeding Study Group. Esophageal balloon tamponade versus esophageal stent in controlling acute refractory variceal bleeding: a multicenter randomized, controlled trial. Hepatology 2016; 63 (06) 1957-1967
- 67 Marot A, Trépo E, Doerig C, Moreno C, Moradpour D, Deltenre P. Systematic review with meta-analysis: self-expanding metal stents in patients with cirrhosis and severe or refractory oesophageal variceal bleeding. Aliment Pharmacol Ther 2015; 42 (11-12): 1250-1260
- 68 Changela K, Ona MA, Anand S, Duddempudi S. Self-expanding metal stent (SEMS): an innovative rescue therapy for refractory acute variceal bleeding. Endosc Int Open 2014; 2 (04) E244-E251
- 69 Boyer TD, Haskal ZJ. American Association for the Study of Liver Diseases Practice Guidelines: the role of transjugular intrahepatic portosystemic shunt creation in the management of portal hypertension. J Vasc Interv Radiol 2005; 16 (05) 615-629
- 70 Boyer TD, Haskal ZJ. ; American Association for the Study of Liver Diseases. The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension: update 2009. Hepatology 2010; 51 (01) 306
- 71 Dariushnia SR, Haskal ZJ, Midia M. , et al; Society of Interventional Radiology Standards of Practice Committee. Quality improvement guidelines for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 2016; 27 (01) 1-7
- 72 Moitinho E, Escorsell A, Bandi JC. , et al. Prognostic value of early measurements of portal pressure in acute variceal bleeding. Gastroenterology 1999; 117 (03) 626-631
- 73 Abraldes JG, Villanueva C, Bañares R. , et al; Spanish Cooperative Group for Portal Hypertension and Variceal Bleeding. Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy. J Hepatol 2008; 48 (02) 229-236
- 74 Rajan DK, Haskal ZJ, Clark TW. Serum bilirubin and early mortality after transjugular intrahepatic portosystemic shunts: results of a multivariate analysis. J Vasc Interv Radiol 2002; 13 (2, Pt 1): 155-161
- 75 Parvinian A, Gaba RC. Outcomes of TIPS for treatment of gastroesophageal variceal hemorrhage. Semin Intervent Radiol 2014; 31 (03) 252-257
- 76 Kamath PS, Wiesner RH, Malinchoc M. , et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33 (02) 464-470
- 77 Salerno F, Merli M, Cazzaniga M. , et al. MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol 2002; 36 (04) 494-500
- 78 Ferral H, Gamboa P, Postoak DW. , et al. Survival after elective transjugular intrahepatic portosystemic shunt creation: prediction with model for end-stage liver disease score. Radiology 2004; 231 (01) 231-236
- 79 Schepke M, Roth F, Fimmers R. , et al. Comparison of MELD, Child-Pugh, and Emory model for the prediction of survival in patients undergoing transjugular intrahepatic portosystemic shunting. Am J Gastroenterol 2003; 98 (05) 1167-1174
- 80 Rudler M, Bureau C, Carbonell N. , et al; French Club for the Study of Portal Hypertension (CFEHTP). Recalibrated MELD and hepatic encephalopathy are prognostic factors in cirrhotic patients with acute variceal bleeding. Liver Int 2018; 38 (03) 469-476
- 81 Allegretti AS, Frenk NE, Li DK. , et al. Evaluation of model performance to predict survival after transjugular intrahepatic portosystemic shunt placement. PLoS One 2019; 14 (05) e0217442
- 82 Maimone S, Saffioti F, Filomia R. , et al. Predictors of re-bleeding and mortality among patients with refractory variceal bleeding undergoing salvage transjugular intrahepatic portosystemic shunt (TIPS). Dig Dis Sci 2019; 64 (05) 1335-1345
- 83 Gaba RC, Couture PM, Bui JT. , et al. Prognostic capability of different liver disease scoring systems for prediction of early mortality after transjugular intrahepatic portosystemic shunt creation. J Vasc Interv Radiol 2013; 24 (03) 411-420 , 420.e1–420.e4, quiz 421
- 84 Casadaban LC, Parvinian A, Zivin SP. , et al. MELD score for prediction of survival after emergent TIPS for acute variceal hemorrhage: derivation and validation in a 101-patient cohort. Ann Hepatol 2015; 14 (03) 380-388
- 85 Conejo I, Guardascione MA, Tandon P. , et al. Multicenter external validation of risk stratification criteria for patients with variceal bleeding. Clin Gastroenterol Hepatol 2018; 16 (01) 132-139.e8
- 86 Lipnik AJ, Pandhi MB, Khabbaz RC, Gaba RC. Endovascular treatment for variceal hemorrhage: TIPS, BRTO, and combined approaches. Semin Intervent Radiol 2018; 35 (03) 169-184
- 87 Kalva SP, Salazar GM, Walker TG. Transjugular intrahepatic portosystemic shunt for acute variceal hemorrhage. Tech Vasc Interv Radiol 2009; 12 (02) 92-101
- 88 Gaba RC, Khiatani VL, Knuttinen MG. , et al. Comprehensive review of TIPS technical complications and how to avoid them. AJR Am J Roentgenol 2011; 196 (03) 675-685
- 89 Gaba RC. Transjugular intrahepatic portosystemic shunt creation with embolization or obliteration for variceal bleeding. Tech Vasc Interv Radiol 2016; 19 (01) 21-35
- 90 Gupta AC, Wang W, Shah C. , et al. Added value of covered stents in transjugular intrahepatic portosystemic shunt: a large single-center experience. Cardiovasc Intervent Radiol 2017; 40 (11) 1723-1731
- 91 Jung HS, Kalva SP, Greenfield AJ. , et al. TIPS: comparison of shunt patency and clinical outcomes between bare stents and expanded polytetrafluoroethylene stent-grafts. J Vasc Interv Radiol 2009; 20 (02) 180-185
- 92 Charon J-PM, Alaeddin FH, Pimpalwar SA. , et al. Results of a retrospective multicenter trial of the Viatorr expanded polytetrafluoroethylene-covered stent-graft for transjugular intrahepatic portosystemic shunt creation. J Vasc Interv Radiol 2004; 15 (11) 1219-1230
- 93 Bucsics T, Schoder M, Diermayr M. , et al. Transjugular intrahepatic portosystemic shunts (TIPS) for the prevention of variceal re-bleeding - a two decades experience. PLoS One 2018; 13 (01) e0189414
- 94 Bucsics T, Schoder M, Goeschl N. , et al. Re-bleeding rates and survival after early transjugular intrahepatic portosystemic shunt (TIPS) in clinical practice. Dig Liver Dis 2017; 49 (12) 1360-1367
- 95 Gaba RC, Couture PM, Lakhoo J. Gastroesophageal variceal filling and drainage pathways: an angiographic description of afferent and efferent venous anatomic patterns. J Clin Imaging Sci 2015; 5 (01) 61-66
- 96 Malloy PC, Grassi CJ, Kundu S. , et al; Standards of Practice Committee with Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Endorsement. Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol 2009; 20 (7, Suppl): S240-S249
- 97 Lopera JE. Role of emergency transjugular intrahepatic portosystemic shunts. Semin Intervent Radiol 2005; 22 (04) 253-265
- 98 Azoulay D, Castaing D, Majno P. , et al. Salvage transjugular intrahepatic portosystemic shunt for uncontrolled variceal bleeding in patients with decompensated cirrhosis. J Hepatol 2001; 35 (05) 590-597
- 99 Helton WS, Belshaw A, Althaus S, Park S, Coldwell D, Johansen K. Critical appraisal of the angiographic portacaval shunt (TIPS). Am J Surg 1993; 165 (05) 566-571
- 100 Rössle M, Haag K, Ochs A. , et al. The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med 1994; 330 (03) 165-171
- 101 LaBerge JM, Ring EJ, Gordon RL. , et al. Creation of transjugular intrahepatic portosystemic shunts with the Wallstent endoprosthesis: results in 100 patients. Radiology 1993; 187 (02) 413-420
- 102 McCormick PA, Dick R, Panagou EB. , et al. Emergency transjugular intrahepatic portasystemic stent shunting as salvage treatment for uncontrolled variceal bleeding. Br J Surg 1994; 81 (09) 1324-1327
- 103 Le Moine O, Devière J, Ghysels M. , et al. Transjugular intrahepatic portosystemic stent shunt as a rescue treatment after sclerotherapy failure in variceal bleeding. Scand J Gastroenterol Suppl 1994; 207: 23-28
- 104 Jalan R, Elton RA, Redhead DN, Finlayson ND, Hayes PC. Analysis of prognostic variables in the prediction of mortality, shunt failure, variceal rebleeding and encephalopathy following the transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage. J Hepatol 1995; 23 (02) 123-128
- 105 Sanyal AJ, Freedman AM, Luketic VA. , et al. Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy. Gastroenterology 1996; 111 (01) 138-146
- 106 Tyburski JG, Noorily MJ, Wilson RF. Prognostic factors with the use of the transjugular intrahepatic portosystemic shunt for bleeding varices. Arch Surg 1997; 132 (06) 626-630 , discussion 630–632
- 107 Chau TN, Patch D, Chan YW, Nagral A, Dick R, Burroughs AK. “Salvage” transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Gastroenterology 1998; 114 (05) 981-987
- 108 Patch D, Nikolopoulou V, McCormick A. , et al. Factors related to early mortality after transjugular intrahepatic portosystemic shunt for failed endoscopic therapy in acute variceal bleeding. J Hepatol 1998; 28 (03) 454-460
- 109 Gerbes AL, Gülberg V, Waggershauser T, Holl J, Reiser M. Transjugular intrahepatic portosystemic shunt (TIPS) for variceal bleeding in portal hypertension: comparison of emergency and elective interventions. Dig Dis Sci 1998; 43 (11) 2463-2469
- 110 Saxon RR, Mendel-Hartvig J, Corless CL. , et al. Bile duct injury as a major cause of stenosis and occlusion in transjugular intrahepatic portosystemic shunts: comparative histopathologic analysis in humans and swine. J Vasc Interv Radiol 1996; 7 (04) 487-497
- 111 Loffroy R, Favelier S, Pottecher P. , et al. Transjugular intrahepatic portosystemic shunt for acute variceal gastrointestinal bleeding: Indications, techniques and outcomes. Diagn Interv Imaging 2015; 96 (7-8): 745-755
- 112 Perello MP, Mur JP, Vives MS. , et al. Long-term follow-up of transjugular intrahepatic portosystemic shunt (TIPS) with stent-graft. Diagn Interv Radiol 2019; 25 (05) 346-352
- 113 Gaba RC, Omene BO, Podczerwinski ES. , et al. TIPS for treatment of variceal hemorrhage: clinical outcomes in 128 patients at a single institution over a 12-year period. J Vasc Interv Radiol 2012; 23 (02) 227-235
- 114 Zhu Y, Wang X, Xi X, Li X, Luo X, Yang L. Emergency transjugular intrahepatic portosystemic shunt: an effective and safe treatment for uncontrolled variceal bleeding. J Gastrointest Surg 2019; 23 (11) 2193-2200
- 115 Orloff MJ, Hye RJ, Wheeler HO. , et al. Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis. Surgery 2015; 157 (06) 1028-1045
- 116 Orloff MJ, Vaida F, Haynes KS, Hye RJ, Isenberg JI, Jinich-Brook H. Randomized controlled trial of emergency transjugular intrahepatic portosystemic shunt versus emergency portacaval shunt treatment of acute bleeding esophageal varices in cirrhosis. J Gastrointest Surg 2012; 16 (11) 2094-2111
- 117 Rosemurgy AS, Frohman HA, Teta AF, Luberice K, Ross SB. Prosthetic H-graft portacaval shunts vs transjugular intrahepatic portasystemic stent shunts: 18-year follow-up of a randomized trial. J Am Coll Surg 2012; 214 (04) 445-453 , discussion 453–455
- 118 Henderson JM. Surgery versus transjugular intrahepatic portal systemic shunt in the treatment of severe variceal bleeding. Clin Liver Dis 2006; 10 (03) 599-612 , ix
- 119 Barange K, Péron J-M, Imani K. , et al. Transjugular intrahepatic portosystemic shunt in the treatment of refractory bleeding from ruptured gastric varices. Hepatology 1999; 30 (05) 1139-1143
- 120 Lo GH, Liang HL, Chen WC. , et al. A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy 2007; 39 (08) 679-685
- 121 Lakhoo J, Bui JT, Lokken RP, Ray Jr CE, Gaba RC. Transjugular intrahepatic portosystemic shunt creation and variceal coil or plug embolization ineffectively attain gastric variceal decompression or occlusion: results of a 26-patient retrospective study. J Vasc Interv Radiol 2016; 27 (07) 1001-1011
- 122 Garcia-Tsao G. Management of acute variceal hemorrhage as a model of individualized care for patients with cirrhosis. Clin Gastroenterol Hepatol 2018; 16 (01) 24-26
- 123 Monescillo A, Martínez-Lagares F, Ruiz-del-Arbol L. , et al. Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology 2004; 40 (04) 793-801
- 124 García-Pagán JC, Caca K, Bureau C. , et al; Early TIPS (Transjugular Intrahepatic Portosystemic Shunt) Cooperative Study Group. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med 2010; 362 (25) 2370-2379
- 125 Garcia-Pagán JC, Di Pascoli M, Caca K. , et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study. J Hepatol 2013; 58 (01) 45-50
- 126 Rudler M, Cluzel P, Corvec TL. , et al. Early-TIPSS placement prevents rebleeding in high-risk patients with variceal bleeding, without improving survival. Aliment Pharmacol Ther 2014; 40 (09) 1074-1080
- 127 Lv Y, Yang Z, Liu L. , et al; AVB-TIPS Study Group. Early TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: a randomised controlled trial. Lancet Gastroenterol Hepatol 2019; 4 (08) 587-598
- 128 Deltenre P, Trépo E, Rudler M. , et al. Early transjugular intrahepatic portosystemic shunt in cirrhotic patients with acute variceal bleeding: a systematic review and meta-analysis of controlled trials. Eur J Gastroenterol Hepatol 2015; 27 (09) e1-e9
- 129 Halabi SA, Sawas T, Sadat B. , et al. Early TIPS versus endoscopic therapy for secondary prophylaxis after management of acute esophageal variceal bleeding in cirrhotic patients: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol 2016; 31 (09) 1519-1526
- 130 Njei B, McCarty TR, Laine L. Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding. J Gastroenterol Hepatol 2017; 32 (04) 852-858
- 131 Sahagun G, Benner KG, Saxon R. , et al. Outcome of 100 patients after transjugular intrahepatic portosystemic shunt for variceal hemorrhage. Am J Gastroenterol 1997; 92 (09) 1444-1452
- 132 Tesdal IK, Filser T, Weiss C, Holm E, Dueber C, Jaschke W. Transjugular intrahepatic portosystemic shunts: adjunctive embolotherapy of gastroesophageal collateral vessels in the prevention of variceal rebleeding. Radiology 2005; 236 (01) 360-367
- 133 Wei B, Chen S, Li X, Tang CW. [Prevention of variceal rebleeding by TIPS combined with embolization of gastric coronary veins: a clinical controlled study]. Zhonghua Gan Zang Bing Za Zhi 2011; 19 (07) 494-497
- 134 Chen S, Li X, Wei B. , et al. Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology 2013; 268 (03) 900-906
- 135 Wu XJ, Cao JM, Han JM, Li JS. [Long-term results of TIPS, TIPS with CVO and combined TIPS and portal azygous disconnection for the treatment of portal hypertension]. Zhonghua Wai Ke Za Zhi 2009; 47 (06) 446-449
- 136 Shi Y, Tian X, Hu J. , et al. Efficacy of transjugular intrahepatic portosystemic shunt with adjunctive embolotherapy with cyanoacrylate for esophageal variceal bleeding. Dig Dis Sci 2014; 59 (09) 2325-2332
- 137 Xue H, Yuan J, Chao-Li Y. , et al. Follow-up study of transjugular intrahepatic portosystemic shunt in the treatment of portal hypertension. Dig Dis Sci 2011; 56 (11) 3350-3356
- 138 Xiao T, Chen L, Chen W. , et al. Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone versus TIPS combined with embolotherapy in advanced cirrhosis: a retrospective study. J Clin Gastroenterol 2011; 45 (07) 643-650
- 139 Qi X, Liu L, Bai M. , et al. Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: a meta-analysis. J Gastroenterol Hepatol 2014; 29 (04) 688-696
- 140 Schultheiß M, Giesler M, Maruschke L. , et al. Adjuvant transjugular variceal occlusion at creation of a transjugular intrahepatic portosystemic shunt (TIPS): efficacy and risks of bucrylate embolization. Cardiovasc Intervent Radiol 2019; 42 (05) 729-736