CC BY 4.0 · TH Open 2020; 04(02): e77-e79
DOI: 10.1055/s-0039-3402024
Case Report
Georg Thieme Verlag KG Stuttgart · New York

A Case of Acquired Factor V Deficiency in Patient with Bleeding

Davide Vetri
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
,
Giovanni Lumera
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
,
Salvatore Tarascio
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
,
Salvatore Scuto
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
,
Elisa Marino
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
,
Giuliana Barcellona
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
,
Salvatore Santo Signorelli
1   Department of Clinical and Experimental Medicine, University of Catania, Catania, Sicily, Italy
› Author Affiliations
Further Information

Publication History

28 May 2019

11 November 2019

Publication Date:
20 April 2020 (online)

Abstract

Low frequency of rare diseases origins from missed diagnosis addressing to poor prognosis. Acquired factor V inhibitor is a very low frequent bleeding condition (prevalence: 0.09/100,000,000–0.29/1,000,000 per year). Antibiotics, surgery, bacterial infections, malignancies, and autoimmune diseases are predisposing factors; however, no predisposing factor was found often. Authors reported a case of bleeding originating from an acquired factor V deficiency because they wish to draw attention to unfrequented or rare clinical situations rarely diagnosed in internal medicine unit.

 
  • References

  • 1 Ortel TL. Clinical and laboratory manifestations of anti-factor V antibodies. J Lab Clin Med 1999; 133 (04) 326-334
  • 2 Ang AL, Kuperan P, Ng CH, Ng HJ. Acquired factor V inhibitor. A problem-based systematic review. Thromb Haemost 2009; 101 (05) 852-859
  • 3 Franchini M, Lippi G. Acquired factor V inhibitors: a systematic review. J Thromb Thrombolysis 2011; 31 (04) 449-457
  • 4 Colomba D, Di Raimondo D, Marino L, Marrone R, Licata G. Acquired haemophilia A: a case report. Intern Emerg Med 2010; 5 (02) 169-171
  • 5 Quek JKS, Wong WH, Tan CW. , et al. Acquired factor V deficiency in a patient with myeloma and amyloidosis. Thromb Res 2018; 164: 1-3
  • 6 Sosa IR, Ellery P, Mast A, Neff AT, Gailani D. Acquired factor V deficiency in a patient without evidence of a classical inhibitor. Haemophilia 2014; 20 (01) e81-e83