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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2020; 55(04): 470-475
DOI: 10.1055/s-0039-3402456
Artigos Originais
Ombro e Cotovelo

Family Predisposition for Rotator Cuff Tear and Other Tendinopathies – A Case-Control Study[*]

Article in several languages: português | English
Jorge Henrique Assunção 
1   Grupo de Ombro e Cotovelo, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
,
Breno Faria Tenrreiro
1   Grupo de Ombro e Cotovelo, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
,
Mauro Emilio Conforto Gracitelli
1   Grupo de Ombro e Cotovelo, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
,
Eduardo Angeli Malavolta
1   Grupo de Ombro e Cotovelo, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
,
Arnaldo Amado Ferreira Neto
1   Grupo de Ombro e Cotovelo, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
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Abstract

Objective To evaluate the prevalence of family history of rotator cuff tear and the presence of tendinopathy in other joints in patients with rotator cuff tears and to compare them with paired controls. To estimate the odds ratio for rotator cuff tear for these two risk factors.

Methods We performed a case-control study comparing patients submitted to treatment for rotator cuff tear with asymptomatic controls. All cases and controls were evaluated by imaging exams and matched by age (±2 years) and gender. We conducted an interview using a standardized questionnaire, and collected data on various risk factors.

Results We evaluated 144 patients, 72 per group. Patients with rotator cuff tears reported a higher number of consanguineous relatives who underwent treatment for the same disease and tendon injuries in other joints compared to the controls (p = 0.005 and p = 0.045 respectively). Individuals with a family history of treatment for rotator cuff tear or with tendinopathies in other joints were more likely to present a rotator cuff tear, with odds ratios of 3.3 (95% confidence interval [95%CI] = 1.4–7.7) and 2.7 (95%CI = 1.1–6.9) respectively.

Conclusions Patients with rotator cuff tear have a higher prevalence of family members with the same disease and tendinopathies or tendon injuries in other joints. The presence of consanguineous relatives with treatment for rotator cuff and tendinopathies in other joints are risk factors for the presence of rotator cuff tears.

Keywords

rotator cuff - genetics - tendinopathy - family history

* Work developed at the Shoulder and Elbow Group, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.




Publication History

Received: 11 September 2018

Accepted: 26 February 2019

Article published online:
27 February 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda
Rio de Janeiro, Brazil

 

  • Referências

  • 1 Mitchell C, Adebajo A, Hay E, Carr A. Shoulder pain: diagnosis and management in primary care. BMJ 2005; 331 (7525): 1124-1128
    CrossrefPubMedGoogle Scholar
  • 2 Yamamoto A, Takagishi K, Osawa T. , et al. Prevalence and risk factors of a rotator cuff tear in the general population. J Shoulder Elbow Surg 2010; 19 (01) 116-120
    CrossrefPubMedGoogle Scholar
  • 3 Malavolta EA, Assunção JH, Beraldo RA, Pinto GMR, Gracitelli MEC, Ferreira Neto AA. Rotator cuff repair in the Brazilian Unified Health System: Brazilian trends from 2003 to 2015. Rev Bras Ortop 2017; 52 (04) 501-505
    Google Scholar
  • 4 Checchia SL, Doneux S, Miyazaki AN. , et al. Avaliação dos resultados obtidos na reparação artroscópica das lesões do manguito rotador. Rev Bras Ortop 2005; 40 (05) 229-238
    Google Scholar
  • 5 Godinho GG, França FO, Freitas JMA. , et al. Avaliação da integridade anatômica por exame de ultrassom e funcional pelo índice de Constant & Murley do manguito rotador após reparo artroscópico. Rev Bras Ortop 2010; 45 (02) 174-180
    CrossrefPubMedGoogle Scholar
  • 6 Antonio M, Veado C, Afonso I, Filho A, Duarte RG, Leitão I. Avaliação funcional do reparo artroscópico das lesões completas do manguito rotador associado a acromioplastia. Rev Bras Ortop 2008; 43 (11/12): 505-512
    CrossrefGoogle Scholar
  • 7 Longo UG, Berton A, Khan WS, Maffulli N, Denaro V. Histopathology of rotator cuff tears. Sports Med Arthrosc Rev 2011; 19 (03) 227-236
    CrossrefPubMedGoogle Scholar
  • 8 Maffulli N, Longo UG, Berton A, Loppini M, Denaro V. Biological factors in the pathogenesis of rotator cuff tears. Sports Med Arthrosc Rev 2011; 19 (03) 194-201
    CrossrefPubMedGoogle Scholar
  • 9 DE Giorgi S, Saracino M, Castagna A. Degenerative disease in rotator cuff tears: what are the biochemical and histological changes?. Joints 2014; 2 (01) 26-28
    PubMedGoogle Scholar
  • 10 Magra M, Maffulli N. Genetic aspects of tendinopathy. J Sci Med Sport 2008; 11 (03) 243-247
    CrossrefPubMedGoogle Scholar
  • 11 Harvie P, Ostlere SJ, Teh J. , et al. Genetic influences in the aetiology of tears of the rotator cuff. Sibling risk of a full-thickness tear. J Bone Joint Surg Br 2004; 86 (05) 696-700
    CrossrefPubMedGoogle Scholar
  • 12 Tashjian RZ, Farnham JM, Albright FS, Teerlink CC, Cannon-Albright LA. Evidence for an inherited predisposition contributing to the risk for rotator cuff disease. J Bone Joint Surg Am 2009; 91 (05) 1136-1142
    CrossrefPubMedGoogle Scholar
  • 13 Tashjian RZ, Saltzman EG, Granger EK, Hung M. Incidence of familial tendon dysfunction in patients with full-thickness rotator cuff tears. Open Access J Sports Med 2014; 5: 137-141
    CrossrefPubMedGoogle Scholar
  • 14 Titchener AG, White JJ, Hinchliffe SR, Tambe AA, Hubbard RB, Clark DI. Comorbidities in rotator cuff disease: a case-control study. J Shoulder Elbow Surg 2014; 23 (09) 1282-1288
    CrossrefPubMedGoogle Scholar
  • 15 Tashjian RZ, Farnham JM, Granger EK, Teerlink CC, Cannon-Albright LA. Evidence for an Environmental and Inherited Predisposition Contributing to the Risk for Global Tendinopathies or Compression Neuropathies in Patients With Rotator Cuff Tears. Orthop J Sports Med 2016; 4 (04) 2325967116642173
    CrossrefPubMedGoogle Scholar
  • 16 September AV, Schwellnus MP, Collins M. Tendon and ligament injuries: the genetic component. Br J Sports Med 2007; 41 (04) 241-246 , discussion 246
    CrossrefPubMedGoogle Scholar
  • 17 Motta GdaR, Amaral MV, Rezende E. , et al. Evidence of genetic variations associated with rotator cuff disease. J Shoulder Elbow Surg 2014; 23 (02) 227-235
    CrossrefPubMedGoogle Scholar
  • 18 Teerlink CC, Cannon-Albright LA, Tashjian RZ. Significant association of full-thickness rotator cuff tears and estrogen-related receptor-β (ESRRB). J Shoulder Elbow Surg 2015; 24 (02) e31-e35
    CrossrefPubMedGoogle Scholar
  • 19 Assunção JH, Godoy-Santos AL, Dos Santos MCLG, Malavolta EA, Gracitelli MEC, Ferreira Neto AA. Matrix Metalloproteases 1 and 3 Promoter Gene Polymorphism Is Associated With Rotator Cuff Tear. Clin Orthop Relat Res 2017; 475 (07) 1904-1910
    CrossrefPubMedGoogle Scholar
  • 20 Kluger R, Burgstaller J, Vogl C, Brem G, Skultety M, Mueller S. Candidate gene approach identifies six SNPs in tenascin-C (TNC) associated with degenerative rotator cuff tears. J Orthop Res 2017; 35 (04) 894-901
    CrossrefPubMedGoogle Scholar
  • 21 Mokone GG, Gajjar M, September AV. , et al. The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries. Am J Sports Med 2005; 33 (07) 1016-1021
    CrossrefPubMedGoogle Scholar
  • 22 Godoy-Santos A, Cunha MV, Ortiz RT, Fernandes TD, Mattar Jr R, dos Santos MCLG. MMP-1 promoter polymorphism is associated with primary tendinopathy of the posterior tibial tendon. J Orthop Res 2013; 31 (07) 1103-1107
    CrossrefPubMedGoogle Scholar
  • 23 Saunders CJ, van der Merwe L, Posthumus M. , et al. Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations. J Orthop Res 2013; 31 (04) 632-637
    CrossrefPubMedGoogle Scholar
  • 24 Gumina S, Candela V, Passaretti D. , et al. The association between body fat and rotator cuff tear: the influence on rotator cuff tear sizes. J Shoulder Elbow Surg 2014; 23 (11) 1669-1674
    CrossrefPubMedGoogle Scholar
  • 25 Yamamoto A, Takagishi K, Kobayashi T, Shitara H, Osawa T. Factors involved in the presence of symptoms associated with rotator cuff tears: a comparison of asymptomatic and symptomatic rotator cuff tears in the general population. J Shoulder Elbow Surg 2011; 20 (07) 1133-1137
    CrossrefPubMedGoogle Scholar
  • 26 Tempelhof S, Rupp S, Seil R. Age-related prevalence of rotator cuff tears in asymptomatic shoulders. J Shoulder Elbow Surg 1999; 8 (04) 296-299
    CrossrefPubMedGoogle Scholar