Pneumologie 2020; 74(S 01): 68
DOI: 10.1055/s-0039-3403209
Posterbegehung (PO11) – Sektion Klinische Pneumologie
Klinische Aspekte der COPD
Georg Thieme Verlag KG Stuttgart · New York

CAT score single item analysis in patients with COPD: results from COSYCONET

M von Siemens
1   Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine
,
P Alter
2   Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University of Marburg (Umr)
,
J Lutter
3   Helmholtz Zentrum München, Institut für Gesundheitsökonomie und Management Im Gesundheitswesen; Comprehensive Pneumology Center Munich (Cpc-M), Mitglied des Deutschen Zentrums für Lungenforschung (Dzl)
,
HU Kauczor
4   Klinik für Diagnostische und Interventionelle Radiologie
,
BJ Jobst
5   Department of Diagnostic & Interventional Radiology with Nuclear Medicine, Thoraxklinik at the Radiologische Klinik
,
R Bals
6   Innere Medizin V, Pneumologie, Universitätsklinikum des Saarlandes, Homburg
,
FC Trudzinski
7   Innere Medizin V, Pneumologie, Universitätsklinikum des Saarlandes, Homburg
,
S Söhler
8   Philipps-Universität Marburg
,
J Behr
9   Medizinische Klinik und Poliklinik V, Klinikum der LMU München, Comprehensive Pneumology Center
,
H Watz
10   Pneumologisches Forschungsinstitut an der Lungenclinic Grosshansdorf
,
B Waschki
11   Department of General and Interventional Cardiology, University Heart Center Hamburg
,
B Bewig
12   University Hospital of Schleswig-Holstein, Campus Kiel
,
P Jones
13   Glaxosmithkline GmbH & Cokg
,
T Welte
14   Klinik für Pneumologie, Medizinische Hochschule Hannover
,
C Vogelmeier
15   Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Phillips-University Marburg, Germany, Member of the German Centre for Lung Research (Dzl), Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg; Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, German Center for Lung Research (Dzl), Marburg, Germany
,
R Jörres
16   Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Klinikum der Universität München; LMU München
,
K Kahnert
17   Department of Internal Medicine V, Respiratory Medicine and Thoracic Oncology, Thoracic Oncology Centre Munich, Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (Dzl Cpc-M)
› Author Affiliations
Further Information

Publication History

Publication Date:
28 February 2020 (online)

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The COPD Assessment Test (CAT) is in widespread use for the evaluation of patients with chronic obstructive pulmonary disease (COPD). We assessed whether the CAT items carry additional information beyond the sum score regarding COPD characteristics including emphysema.

Patients of GOLD grades 1 to 4 from the COPD cohort COSYCONET (German COPD and Systemic Consequences – Comorbidities Network) with complete CAT data were included (n = 2270), of whom 493 had chest CT evaluated for the presence of emphysema. Comorbidities and lung function were assessed following standardised procedures. Cross-sectional data analysis was based on multiple regression analysis of the single CAT items against a panel of comorbidities, lung function, or CT characteristics (qualitative score, 15th percentile of mean lung density), with age, BMI and gender as covariates. This was supported by exploratory factor analysis.

Regarding the relationship to comorbidities and emphysema, there were marked differences between CAT items, especially items 1 and 2 versus 3 to 8. This grouping was basically confirmed by factor analysis. Items 4 and 5, and to a lower degree 1, 2 and 6, appeared to be informative regarding the presence of emphysema, whereas the total score was not or less informative. Regarding comorbidities, similar findings as for the total CAT score were obtained for the modified Medical Research Council scale (mMRC) which was also informative regarding emphysema.

Our findings suggest that the usefulness of the CAT can be increased if evaluated on the basis of single items which may be indicating the presence of comorbidities and emphysema.