Klin Padiatr 2020; 232(02): 109-110
DOI: 10.1055/s-0040-1701933
16 May 2020
S-IX
Session IX: Staging Evaluation and Response Criteria Harmonization (SEARCH) for CAYAHL
© Georg Thieme Verlag KG Stuttgart · New York

Nodular sclerosis lymphoma - the new radiology sign

HM Lederman
1   Radiology, IOP-GRAACC, Sao Paulo, Brazil
,
DC Grassi
1   Radiology, IOP-GRAACC, Sao Paulo, Brazil
,
I Grossman
1   Radiology, IOP-GRAACC, Sao Paulo, Brazil
,
F Luisi
2   Oncology, IOP-GRAACC, Sao Paulo, Brazil
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2020 (online)

Also available at
 

Content Objective To define a new radiological sign, the central hypo-attenuated lymph node in nodular sclerosis in Hodgkin’s lymphoma in computed tomography (CT).

Materials and methods Throughout the last year, all patients diagnosed with lymphoma were CT - scanned with intravenous non-ionic contrast. CT scans were evaluated by an expert pediatric radiologist and were later pathology- proven to be nodular sclerosis type.

Results 7 newly-diagnosed cases of nodular sclerosis Hodgkin’s lymphoma presented with the central hypo-attenuation of the compromised lymph nodes in the CT-scans. All of them were pathology-proven diagnosed with nodular sclerosis Hodgkin’s lymphoma.

Discussion We propose that the central hypo-attenuated lymph node sign is because of the accumulated lymph inside the compromised lymph node. This finding has been proven with pathology by the presence of collagen bands in the lymph node periphery. There’s still work to be done, a systematic retrospective study on all Hodgkin’s lymphoma at the moment of the diagnosis will determine the sensitivity, specificity, positive predictive value, and negative predictive values for this new radiologic sign.

 

  • References

  • 1 Sherief LM, Elsafy UR, Abdelkhalek ER. , et al. Hodgkin lymphoma in childhood: clinicopathological features and therapy outcome at 2 centers from a developing country. Medicine (Baltimore). 2015; 94 (15) : e670 . doi:10.1097/MD.0000000000000670
    PubMedGoogle Scholar
  • 2 Pileri SA, Ascani S, Leoncini L. , et al. Hodgkin’s lymphoma: the pathologist’s viewpoint. J Clin Pathol. 2002; 55 (03) : 162-176 . doi:10.1136/jcp.55.3.162
    CrossrefPubMedGoogle Scholar
  • 3 Keraliya AR, Tirumani SH, Shinagare AB, Ramaiya NH. Beyond PET/CT in Hodgkin lymphoma: a comprehensive review of the role of imaging at initial presentation, during follow-up and for assessment of treatment-related complications. Insights Imaging. 2015; 6 (03) : 381-392 . doi:10.1007/s13244-015-0407-z
    CrossrefPubMedGoogle Scholar
  • 4 Paolo Toma, Claudio Granata, Andrea Rossi. , and Alberto Garaventa. Multimodality Imaging of Hodgkin Disease and Non-Hodgkin Lymphomas in Children. RadioGraphics 2007; 27 (05) , 1335-1354
    PubMedGoogle Scholar