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DOI: 10.1055/s-0040-1704244
PATENCY OF EUS-GUIDED GASTROENTEROSTOMY IN THE TREATMENT OF MALIGNANT GASTRIC OUTLET OBSTRUCTION
Publication History
Publication Date:
23 April 2020 (online)
Aims Endoscopic ultrasonography-guided gastroenterostomy (EUS-GE) using a Lumen Apposing Metal Stent (LAMS), is a novel, minimally invasive technique in the palliative treatment of malignant gastric outlet obstruction (GOO). Several studies have demonstrated feasibility and safety of EUS-GE. However, evidence on long-term durability is limited. The aim of this study is to evaluate long-term patency of EUS-GE with a LAMS in the treatment of malignant GOO.
Methods A multicenter international retrospective study was performed in seven centers from four European countries. Patients who underwent EUS-GE with a LAMS (Hot AXIOS stent) between March 2015 and March 2019 for palliative treatment of symptomatic malignant GOO were included. Primary endpoint was recurrent obstruction, secondary endpoints were technical success, clinical success, adverse events and survival.
Results A total of 45 patients (48.9% male; mean age 69.9 ± 12.3 years) were included in this study. Median follow-up was 59 days (IQR 41-128). Recurrent obstruction after initial clinical success occurred in two patients (6.1%), after 33 and 283 days of follow-up. Technical success was achieved in 38 (84.4%) patients. Clinical success was achieved in 33 (73.3%) cases. Adverse events occurred in 12 (26.7%) patients, five (11.1%) of which were fatal.
Conclusions A total of 45 patients (48.9% male; mean age 69.9 ± 12.3 years) were included in this study. Median follow-up was 59 days (IQR 41-128). Recurrent obstruction after initial clinical success occurred in two patients (6.1%), after 33 and 283 days of follow-up. Technical success was achieved in 38 (84.4%) patients. Clinical success was achieved in 33 (73.3%) cases. Adverse events occurred in 12 (26.7%) patients, of which five (11.1%) were fatal.