Endoscopy 2020; 52(S 01): S276-S277
DOI: 10.1055/s-0040-1704874
ESGE Days 2020 ePoster presentations
Colon and rectum 09:00–17:00 Thursday, April 23, 2020 ePoster area
© Georg Thieme Verlag KG Stuttgart · New York

ENDOSCOPIC FULL-THICKNESS RESECTION (EFTR) OF COLORECTAL LESIONS WITH THE FULL-THICKNESS RESECTION DEVICE (FTRD): A RETROSPECTIVE ANALYSIS OF 55 CONSECUTIVE CASES

P Stathopoulos
1   University Hospital Marburg, Department of Gastroenterology and Endocrinology, Marburg, Germany
,
E Gallmeier
1   University Hospital Marburg, Department of Gastroenterology and Endocrinology, Marburg, Germany
,
TM Gress
1   University Hospital Marburg, Department of Gastroenterology and Endocrinology, Marburg, Germany
,
C Denkert
2   University Hospital Marburg, Institute of Pathology, Marburg, Germany
,
U Denzer
1   University Hospital Marburg, Department of Gastroenterology and Endocrinology, Marburg, Germany
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Publikationsdatum:
23. April 2020 (online)

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Aims EFTR is an emerging therapeutic option for endoscopic resection of lesions, which cannot be adequately and/or safely treated with conventional endoscopic techniques (EMR and ESD), such as epithelial neoplasia extending deeper than the mucosa or associated with significant fibrosis. In this single-center, retrospective study we aimed to evaluate the efficacy and safety of EFTR of colorectal lesions in various indications using the FTRD.

Methods We performed a retrospective analysis of 55 consecutive patients, who were admitted to our center between November 2016 and November 2019. The EFTR was conducted using the FTRD System (OVESCO, Tübingen, Germany).

Results 55 patients (18 females, 37 males, mean age 69 years) underwent EFTR in our center. The 34 in colon and 21 in rectum located lesions (lesion mean size 12 mm, range 4–26) were all endoscopically reached. The indications included 36 adenomas (recurrent/residual adenomas, adenomas with non-lifting sign), 11 T1 adenocarcinomas, 6 neuroendocrine tumors, one subepithelial tumor and a patient with suspected Hirschsprung disease. Three cases were performed due to the lesion size (25–50 mm) as a hybrid technique (combination of EMR and EFTR). Resection was technically successful in 52 patients (94,5%). Histologically complete resection (R0) was achieved in 47 patients (85,5%). The R0 resection rate was 78,2%. 11 adenocarcinomas were histologically proven (R0 in 6/11 cases, 55%). 4 out of 11 patients (3 with sm3 histology und one with R1) underwent oncologic resection, whereas the other patients were followed endoscopically. The total complication rate was 12,7% (4 bleedings, 2 perforations, 1 subileus).

Conclusions Our study, consistent with previously published data, shows favourable results concerning efficacy and safety, especially for benign lesions and neuroendocrine tumors. Even in early colorectal cancer surgery can be avoided in many low risk cases. Thus, prospective studies are required to define indications for early colorectal cancer.