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DOI: 10.1055/s-0040-1705996
Gold Catalysis and Furans: A Powerful Match for Synthetic Connections
We thank the Italian Ministery of Research, the Cassa di Risparmio of Turin and Huvepharma srl for funding.
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Abstract
This review summarizes the advances made on the synthesis and functionalization of furans via gold catalysis during the period between 2016 and 2020. A separate section is dedicated to the tandem gold-catalyzed synthesis and functionalization of furans.
1 Introduction
2 Gold-Catalyzed Synthesis of Furans
2.1 Cycloisomerizations of Alkynyl and Cumulenyl Alcohols
2.2 Cycloisomerizations of Alkynyl and Allenyl Ketones
2.3 Reactions with External Oxidants
2.4 Miscellaneous
3 Gold-Catalyzed Functionalization of Furans
3.1 Cycloadditions
3.2 Furan Ring Decorations
3.3 Reactions Involving Furan Ring Opening
4 Gold-Catalyzed Tandem Synthesis and Functionalization of Furans
4.1 Cycloisomerizations Followed by Gold-Catalyzed Cycloaddition
4.2 Cycloisomerizations to a Gold 1,3- or 1,4-Dipole and Intermolecular Annulation
4.3 Cycloisomerizations to a Gold Carbene and Intermolecular Trapping
5 Conclusion
Key words
gold - furans - tandem reactions - alkynes - cycloisomerization - ring opening - cycloadditionPublication History
Received: 05 October 2020
Accepted after revision: 05 November 2020
Article published online:
21 December 2020
© 2020. Thieme. All rights reserved
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For other examples of 1,2-iodine shifts in gold catalysis, see: