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Synthesis 2021; 53(22): 4231-4238
DOI: 10.1055/s-0040-1706046
DOI: 10.1055/s-0040-1706046
special topic
Special Issue dedicated to Prof. Sarah Reisman, recipient of the 2019 Dr. Margaret Faul Women in Chemistry Award
Synthesis of Borylated Hydrazino Acid Derivatives
The Natural Sciences and Engineering Research Council of Canada is gratefully acknowledged for their financial support. C.-H. T. would like to thank the Connaught Fund (University of Toronto).
Abstract
α-Boryl-α-hydrazinoacetic acid is a highly functionalized boron-containing building block that can be easily accessed from readily available α-borylacetaldehyde. The hydrazine motif can be converted into a variety of α-borylated azoles and diazines in a straightforward protocol. Furthermore, the carboxy group can be derivatized to afford novel organoboron compounds that should find applications in various cross-coupling transformations.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706046.
- Supporting Information
Publication History
Received: 04 April 2021
Accepted after revision: 07 May 2021
Article published online:
31 May 2021
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