Synthesis of Borylated Hydrazino Acid Derivatives

Abstract

α-Boryl-α-hydrazinoacetic acid is a highly functionalized boron-containing building block that can be easily accessed from readily available α-borylacetaldehyde. The hydrazine motif can be converted into a variety of α-borylated azoles and diazines in a straightforward protocol. Furthermore, the carboxy group can be derivatized to afford novel organoboron compounds that should find applications in various cross-coupling transformations.

Key words

hydrazinoboronates - aminoboronic acids - organoboron - borylated heterocycles - BMIDA

Publication History

Received: 04 April 2021

Accepted after revision: 07 May 2021

Article published online:
31 May 2021

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