Alkylzirconocenes in Organic Synthesis: An Overview

Chao Yang; Chao Jiang; Xiangbing Qi

doi:10.1055/s-0040-1706146

Synthesis, Table of Contents

Synthesis 2021; 53(06): 1061-1076
DOI: 10.1055/s-0040-1706146

short review

Alkylzirconocenes in Organic Synthesis: An Overview

Chao Yang

^aSchool of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P. R. of China

^bNational Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, P. R. of China

,

Chao Jiang∗

^aSchool of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P. R. of China

,

Xiangbing Qi ∗

^bNational Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, P. R. of China

^cTsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, P. R. of China

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Abstract

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Abstract

Organozirconium chemistry has found extensive applications in organic synthesis since its discovery in the last century. Alkylzirconocenes, which are easily generated by the hydrozirconation of alkenes with the Schwartz reagent, are widely utilized for carbon–carbon and carbon–heteroatom bond formation. This short review summarizes the progress to date on the applications alkylzirconocenes in organic synthesis.

1 Introduction

2 General Methods for Generating Alkylzirconocenes

3 Transformations of Alkylzirconocenes by Heteroatoms

4 Insertion of Unsaturated Groups into Alkylzirconocenes

5 Transmetalations

6 Cross-Coupling Reactions of Alkylzirconocenes

7 Photochemistry of Alkylzirconocenes

8 Bimetallic Reagents of Zirconium

9 Asymmetric Transformations

10 Applications of Alkylzirconocenes Generated from the Negishi Reagent

11 Conclusions and Outlook

Key words

alkylzirconocenes - organozirconium - hydrozirconation - chain-walking - alkenes

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