Continuous-Flow Reactions Mediated by Main Group Organometallics

Johannes H. Harenberg; Niels Weidmann; Paul Knochel

doi:10.1055/s-0040-1706536

Synlett, Table of Contents

Synlett 2020; 31(19): 1880-1887
DOI: 10.1055/s-0040-1706536

cluster

Integrated Synthesis Using Continuous-Flow Technologies

Continuous-Flow Reactions Mediated by Main Group Organometallics

Johannes H. Harenberg

,

Niels Weidmann

,

Paul Knochel ∗

Abstract

All articles of this category

In memory of Professor Jun-ichi Yoshida

Abstract

The generation of reactive organometallic reagents in batch is often complicated by the low thermal stability of these important synthetic intermediates and can require low reaction temperatures and special reaction conditions. However, the use of continuous-flow setups and microreactors has led to a revolution in this field. In this short review, an overview is given of recent advances in this area, with a focus on the main group organometallics of Li, Na, and K.

Key words

flow chemistry - organolithium compounds - organosodium compounds - organomagnesium compounds - Barbier conditions

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References

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