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Synlett 2020; 31(19): 1880-1887
DOI: 10.1055/s-0040-1706536
DOI: 10.1055/s-0040-1706536
cluster
Integrated Synthesis Using Continuous-Flow Technologies
Continuous-Flow Reactions Mediated by Main Group Organometallics
In memory of Professor Jun-ichi Yoshida
Abstract
The generation of reactive organometallic reagents in batch is often complicated by the low thermal stability of these important synthetic intermediates and can require low reaction temperatures and special reaction conditions. However, the use of continuous-flow setups and microreactors has led to a revolution in this field. In this short review, an overview is given of recent advances in this area, with a focus on the main group organometallics of Li, Na, and K.
Key words
flow chemistry - organolithium compounds - organosodium compounds - organomagnesium compounds - Barbier conditionsPublication History
Received: 07 August 2020
Accepted after revision: 06 September 2020
Article published online:
09 October 2020
© 2020. Thieme. All rights reserved
Georg Thieme Verlag KG
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