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Synlett 2021; 32(01): 69-74
DOI: 10.1055/s-0040-1707192
DOI: 10.1055/s-0040-1707192
letter
Cascade Access to Carboline Carboxylates from Indolyl Ketoximes and Acrylates via Palladium-Catalyzed C–H Bond Alkenylation/Annulation
We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.Further Information
Publication History
Received: 13 May 2020
Accepted after revision: 11 June 2020
Publication Date:
15 July 2020 (online)
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Abstract
An efficient palladium-catalyzed C–H bond alkenylation/annulation strategy to access carboline carboxylates from indolyl ketoximes and acrylates through C–C/C–N bond formation is reported. Indolyl ketoximes not only direct ortho-olefination with acrylates, but also undergo an intramolecular N–O bond cleavage/traceless annulation to construct carboline carboxylates straightforwardly in this concise method.
Key words
carboline carboxylates - alkenylation - annulation - indolyl ketoximes - C–H activation - palladium catalysisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707192.
- Supporting Information