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Synthesis 2020; 52(22): 3466-3472
DOI: 10.1055/s-0040-1707229
DOI: 10.1055/s-0040-1707229
paper
Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides
We are grateful to the Natural Science Foundation of Zhejiang Province (LQ20B020012), the research foundation of Zhejiang University of Technology (2019101000429), and the National Natural Science Foundation of China (No. 21772176 and 21372201) for financial support.Further Information
Publication History
Received: 23 June 2020
Accepted after revision: 03 July 2020
Publication Date:
05 August 2020 (online)
Abstract
We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H2O to access alkyl amides. Bench-stable NiCl2(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707229.
- Supporting Information
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