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Synthesis 2020; 52(22): 3439-3445
DOI: 10.1055/s-0040-1707233
DOI: 10.1055/s-0040-1707233
paper
An Efficient Hydration and Tandem Transfer Hydrogenation of Alkynes for the Synthesis of Alcohol in Water
The authors thank the National Natural Science Foundation of China (21962004, 21562004), Jiangxi Provincial Department of Science and Technology (20192BAB203004), the Jiangxi Education Hall Science and Technology Foundation (GJJ180801), the emergency research project for Gannan Medical University (YJ202027) and the Fundamental Research Funds for Gannan Medical University (QD201810, QD201816) for financial support.Further Information
Publication History
Received: 21 May 2020
Accepted after revision: 09 July 2020
Publication Date:
11 August 2020 (online)
Abstract
A practical and efficient method for the synthesis of alcohols in one pot from readily available alkynes via a tandem process by formic acid promoted hydration and metal-ligand bifunctional iridium-catalyzed transfer hydrogenation under mild conditions has been described. This transformation is simple, efficient, and can be performed with a variety of alkynes in good yields and with excellent stereoselectivities. Experimental results showed high catalytic activity, and turnover frequency (TOF) up to 25000. Importantly, this transformation can be conducted in water, and is thus green and environmentally friendly.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707233.
- Supporting Information
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