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Synthesis 2021; 53(01): 1-29
DOI: 10.1055/s-0040-1707273
DOI: 10.1055/s-0040-1707273
review
Recent Progress in Radical Decarboxylative Functionalizations Enabled by Transition-Metal (Ni, Cu, Fe, Co or Cr) Catalysis
This work was supported by the Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Tsinghua-Peking Centre for Life Science.
Abstract
Aliphatic carboxylic acids are abundant in natural and synthetic sources and are widely used as connection points in many chemical transformations. Radical decarboxylative functionalization promoted by transition-metal catalysis has achieved great success, enabling carboxylic acids to be easily transformed into a wide variety of products. Herein, we highlight the recent advances made on transition-metal (Ni, Cu, Fe, Co or Cr) catalyzed C–X (X = C, N, H, O, B, or Si) bond formation as well as syntheses of ketones, amino acids, alcohols, ethers and difluoromethyl derivatives via radical decarboxylation of carboxylic acids or their derivatives, including, among others, redox-active esters (RAEs), anhydrides, and diacyl peroxides.
1 Introduction
2 Ni-Catalyzed Decarboxylative Functionalizations
3 Cu-Catalyzed Decarboxylative Functionalizations
4 Fe-Catalyzed Decarboxylative Functionalizations
5 Co- and Cr-Catalyzed Decarboxylative Functionalizations
6 Conclusions
Key words
carboxylic acids - decarboxylative functionalization - transition metals - radicals - redox-active esters (RAEs) - C–X bond formation - catalysisPublication History
Received: 24 June 2020
Accepted after revision: 04 August 2020
Article published online:
01 October 2020
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