Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

Zijuan Wang; Wenteng Chen; Chang He; Guolin Zhang; Yongping Yu

doi:10.1055/s-0040-1707329

Synthesis, Inhaltsverzeichnis

Synthesis 2021; 53(07): 1356-1364
DOI: 10.1055/s-0040-1707329

paper

Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

Zijuan Wang

,

Wenteng Chen

,

Chang He

,

Guolin Zhang∗

,

Yongping Yu∗

Abstract

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Abstract

A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed cascade reaction involving C(sp)–C(sp²) coupling followed by intramolecular C–N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator protein (TSPO) ligand.

Key words

4-arylquinazolines - palladium(II) catalysis - one-pot assembly - tandem cyclization reaction - ligands

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Referenzen

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