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Synthesis 2020; 52(24): 3818-3836
DOI: 10.1055/s-0040-1707355
DOI: 10.1055/s-0040-1707355
special topic
Recent Advances in Metal-Catalyzed Ring Construction
Recent Advances in Cycloaddition Reactions with Alkynes to Construct Heterocycles
This research was supported by the National Natural Science Foundation of China (Nos. 21625203 and 21871126).
Abstract
Heterocyclic compounds, especially N-heterocycles and O-heterocycles, are prominent structural motifs present in numerous natural products and medically and/or economically important compounds. This review aims to describe the development of transition-metal-catalyzed cycloaddition reactions of functionalized m-atom partners with alkynes to access a wide range of five-, six-, and seven-membered heterocycles, that is functionalized N-heterocycles and O-heterocycles such as azepines, isoquinolines, isocoumarins, spiroheterocycles, indoles, furans, and pyrroles, in a selectively controlled manner with an emphasis on scope and limitations and with a discussion of the mechanisms.
1 Introduction
2 Intermolecular Cycloaddition To Construct Azepine Derivatives
2.1 [5+2] Cycloaddition
2.2 [3+2+2] Cycloaddition
2.3 [3+2]/[5+2] Cycloaddition
3 Intermolecular [4+2] Cycloaddition To Construct Isoquinolines or Isocoumarins
4 Intermolecular [3+2] Cycloaddition To Construct Spiroheterocyclic Compounds, Indoles, Furans, and Pyrroles
5 Summary and Outlook
Publication History
Received: 30 April 2020
Accepted: 24 July 2020
Article published online:
13 October 2020
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