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Synthesis 2020; 52(17): 2497-2511
DOI: 10.1055/s-0040-1707403
DOI: 10.1055/s-0040-1707403
short review
Tertiary Enamides as Versatile and Valuable Substrates to Reach Chemical Diversity
We thank the Centre National de la Recherche Scientifique (CNRS) and the University of Strasbourg for financial support.Further Information
Publication History
Received: 11 March 2020
Accepted after revision: 28 April 2020
Publication Date:
18 May 2020 (online)
Abstract
Tertiary enamides display versatile reactivity and great stability compared to their enamine congeners. This review covers progress made in the development of new methods involving the enaminic reactivity of tertiary enamides with respect to the synthesis of complex nitrogen-containing compounds. A focus on the preparation of biologically active molecules is also presented. The syntheses reported herein are classified based on their reaction type. In addition, mechanistic insights are given for most of the new transformations.
1 Introduction
2 [2+2] Cycloadditions
3 [4+2] Cycloadditions
4 Electrocyclizations and Cycloisomerizations
5 Sigmatropic Rearrangements
6 Nucleophilic Additions
7 Tertiary Enamides as Electrophiles
8 Cross-Coupling Reactions
9 Tertiary-Enamide-Assisted Reactions
10 Conclusion and Perspectives
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