CC BY 4.0 · Rev Bras Ginecol Obstet 2020; 42(05): 235-239
DOI: 10.1055/s-0040-1709693
Original Article
Obstetrics
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Missed Abortion

1   Department of Obstetrics and Gynecology, School of Medicine, Kütahya Health Sciences University, Kütahya, Turkey
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2   Department of Obstetrics and Gynecology, Florence Nightingale Hospital, Istanbul, Turkey
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3   Private Balkan Hospital, Edirne, Turkey
› Author Affiliations
Further Information

Publication History

06 August 2019

02 March 2020

Publication Date:
29 May 2020 (online)

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Abstract

Objective Missed abortion occurs in ∼ 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered responsible for missed abortion. Platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited parameters of inflammation in the literature. However, no study evaluated the PLR and NLR rates in missed abortions so far. The aim of the present study is to investigate whether complete blood count (CBC) inflammatory parameters such as NLR and PLR are increased in patients with missed abortion.

Methods Medical records of 40 pregnant women whose gestation ended in missed abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women were collected and compared retrospectively. The groups were compared regarding hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), PLR and NLR.

Results Platelet distribution width, NLR and PLR values were higher in the missed abortion group compared with the healthy pregnant women group (rates are p = 0.043; p = 0.038; and p = 0.010, respectively). Hematocrit, MPV, and lymphocyte values were found to be lower in the missed abortion group compared with the healthy pregnant women group (p = 0.027, p = 0.044 and p = 0.025, respectively).

Conclusion The PDW, NLR and PLR values of the missed abortion group were reported high; and MPV values were reported low in the present study. These findings may help to speculate a defective placentation in the pathogenesis of missed abortion.

Contributors

All of the authors participated in the concept and design of the present study; analysis and interpretation of data; drafting or revising of the manuscript, and they have approved the manuscript as submitted. All authors are responsible for the reported research.