Open Access
CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2021; 56(06): 689-696
DOI: 10.1055/s-0040-1709733
Artigo de Atualização
Pé e Tornozelo

Ankle Osteoarthritis[]

Artikel in mehreren Sprachen: português | English
1   Laboratório Prof Manlio Mario Marco Napoli, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil
2   Programa Aparelho Locomotor, Hospital Israelita Albert Einstein, São Paulo, SP, Brasil
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3   Departamento de Ortopedia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
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4   Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, United States
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5   Serviço de Ortopedia e Traumatologia Prof Nova Monteiro, Hospital Municipal Miguel Couto, Rio de Janeiro, SP, Brasil
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6   Swiss Ortho Center, University of Basel, Schmerzklinik Basel, Basel, Suíça
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7   Universitäts Centrum für Orthopädie und Unfallchirurgie, Universitätsklinikum Carl Gustav Carus, Dresden, Alemanha
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Abstract

Osteoarthritis (OA) is characterized by a chronic, progressive and irreversible degradation of the joint surface associated with joint inflammation. The main etiology of ankle OA is post-traumatic and its prevalence is higher among young and obese people. Despite advances in the treatment of fractures around the ankle, the overall risk of developing post-traumatic ankle OA after 20 years is almost 40%, especially in Weber type B and C bimalleolar fractures and in fractures involving the posterior tibial border. In talus fractures, this prevalence approaches 100%, depending on the severity of the lesion and the time of follow-up. In this context, the current understanding of the molecular signaling pathways involved in senescence and chondrocyte apoptosis is fundamental. The treatment of ankle OA is staged and guided by the classification systems and local and patient conditions. The main problems are the limited ability to regenerate articular cartilage, low blood supply, and a shortage of progenitor stem cells.

The present update summarizes recent scientific evidence of post-traumatic ankle OA with a major focus on changes of the synovia, cartilage and synovial fluid; as well as the epidemiology, pathophysiology, clinical implications, treatment options and potential targets for therapeutic agents.

Study performed at the Institute of Orthopedics and Traumatology of the Faculty of Medicine of the Universidade de São Paulo, São Paulo, SP, Brazil.




Publikationsverlauf

Eingereicht: 14. Juli 2019

Angenommen: 10. Januar 2020

Artikel online veröffentlicht:
29. Mai 2020

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