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DOI: 10.1055/s-0040-1710848
Results of the volume of the submandibular gland in an epidemiologic cohort
Introduction Diseases of the submandibular gland are common. Especially in autoimmune diseases like M. Sjögrens, diagnostic and therapy is still a challenge. In this context, the aim oh this study was to develop a reliable protocol and epimdeiologically based normative data for the volume of the submandibular gland and to evluate confounding factors.
Methods Using 100 randomly chosen MRI scans of the Study of Health in Pomerania (SHIP), a protocol was developed and reliability after multiple measurements calculated using Intra-Class-Correlationscoeffizient and a Bland-Altman Plot. With Osirix 3.7.1 3266 data sets were volumetrized in a standardised fashion based on manual segmentation of the individual slides. Both intraglandular vessels or lymph nodes were excluded and previously reported confounding factors analysed.
Results The mean volume of the left submandibular gland was 9,79 ± 2,75 cm 3 and of the right 9,87 ± 2,83 cm 3 (mean ± SD). The volume incerased both with age and in case of male gender. Body Mass Index and height were confounding factors as well.
Discussion: The observed volume was larger than in the literature previously reported. Volume of the submandibular gland may thereby be a sensitive parameter to detect pathophysiologic changes earlier and help to identify previously unknown confounding factors.
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Publication History
Article published online:
10 June 2020
© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
© Georg Thieme Verlag KG
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