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DOI: 10.1055/s-0040-1710969
Retrospective und prospective biomarker studies in early stage HNSCC- first clinical results-
Introduction Biomarkers for locally advanced head and neck squamous cell carcinoma (HNSCC) have previously been identified. The aim of this study is to prove the applicability of these biomarkers in patients with early stage HNSCC who underwent only a surgical therapy. Additionally, we try to classify a low risk and high risk group for relapse with the aid of these biomarkers.
Methods Between 2005 and 2014, patients with an early stage HNSCC (UICC I and II, pT1 or pT2, c/pN0 cMo) and performed cancersurgery were included. Three biomarkers (p16, CD44 and p53) were evaluated in the tumor tissue. Patients were subsequently observed in follow-up care concerning a possible relapse of HNSCC (median follow-up was 24 months). The primary endpoint of the study is the local and regional tumor control.
Results Up to this time, 174 patients (123 men and 51 women) with 141 oral cavity cancers, 32 oropharyngeal cancers and one hypopharyngeal cancers were included. 89 % of these patients had pT1 and 11 % had pT2 cancer. p16+ cancers in this group are not significantly associated with local control but with a high regional control. CD44-negative cancers are associated with local control, otherwise a high expression of CD44 is correlated with a bad local control. p53-negativity is associated with a higher local and regional control, but only in oropharyngeal cancers.
Conclusion All three investigated biomarkers are useful as prognostic marker for patients with early stage HNSCC. However, more biomarkers would be required for a better stratification. The validation of biomakers will be performed in the actually rectruted prospective study.
Poster-PDF A-1829.PDF
Publication History
Article published online:
10 June 2020
© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
© Georg Thieme Verlag KG
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