Foreign body reaction after Bioverit II® implantation

Objectives Incompatibility of implant materials may result in foreign body reaction, which in turn may lead to a variety of complications such as infection, triggering aggressive exacerbation of chronic rhinosinusitis, mucocele and biofilm formation. Understanding the pathophysiology of this reaction is important for its management and prevention. The aim of this study is to focus on a case of foreign body reaction after Bioverit II® implantation and its impact on the management of chronic rhinosinusitis.

Methods We investigated a case with foreign body reaction after Bioverit II® implantation retrospectively. The occurrence of the first complication with wound healing disorder and infection took place many months after implantation.

Results Pathological humoral and cellular immune reactions were observed. The analysis of the surrounding tissue after Bioverit II® explantation clearly show a foreign body reaction with polynuclear giant cells. Superinfection and biofilm formation were intermittently observed.

Discussion Generally, the material under investigation is considered immunologically inert. However, the case presented here shows that in an immunologically highly active environment with intrinsic NSAID intolerance, exposition to bacteria and other inflammatory agents, foreign body reaction may be triggered. One approach to management of material incompatibility is explantation of alloplastic material and addressing triggering factors before re-implantation of a new implant is considered

Poster-PDF A-2038.PDF

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Artikel online veröffentlicht:
10. Juni 2020