Evidence of novel objective parameters in diagnosis and course of Sjögren's syndrome

Aim Sjögren’s Syndrome (SS) is the most frequently diagnosed autoimmune disorder in the head and neck region. The classification of primary SS (pSS) is carried out based on the ACR/ EULAR criteria. We evaluated novel objective marker in diagnosis and course of patients with primary SS (pSS).

Methods Patients that were administered to an Department of Otorhinolaryngology and complained about xerostomia and/ or glandular swelling were included. Patients were classified based on aforementioned criteria. We collected symptom scores, results of Schirmer test, Saxon test, autoantibodies (SSA) in serum, and IL-6 in saliva. Ultrasound (US) and Shear wave elastography (SWE) were performed, minor salivary gland biopsy was just performed if necessary. Patients with pSS received local liposomal therpy for 2 months, and symptom scores and glandular tests were reevaluated.

Results Patients with pSS and with idiopathic sicca syndrome (IS) were compared. There was no significance in symptom score, histology of the minor salivary glands, or IL6. But IL6 correlated well with the symptom score of xerostomia. There was a significant difference in Schirmer test, Saxon test, SSA antibodies, US, and SWE. After 2 month of local treatment in the pSS group symtome score for xerostomia and tissue elasticity improved.Conclusion: IL6 and SWE can be used as novel objective parameters in diagnosis and course of pSS.

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Publication History

Article published online:
10 June 2020