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DOI: 10.1055/s-0040-1711444
Applications of stem cells for the regeneration of the inner ear
The restoration of natural hearing is in the focus of the efforts to develop a novel therapy for hearing loss. One of the most promising strategies for regeneration of the inner ear is the use of stem cells.
In the recent past, a number of pioneering studies have shown that there are various options for the use of stem cells for inner ear regeneration which go far beyond cell replacement therapy. Stem cell-based strategies for stimulation of the endogenous potential of the cochlea as well as the use of stem cell-generated inner ear cell types for otoregenerative drug screening are becoming more and more important. The basic principles of the different options for the use of stem cells will be explained and discussed with reference to recent groundbreaking work and own research data.
The ongoing expansion of the spectrum of stem cell-based techniques and applications demonstrates the potential for the development of novel inner ear therapies. A completely regenerative therapy for hearing loss still appears to be far away. However, it is becoming apparent that the use of stem cells may represent an additional therapeutic component in the near future besides established treatment options like modern hearing aid and implant technology.
Poster-PDF A-1923.PDF
Publication History
Article published online:
10 June 2020
© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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