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CC BY 4.0 · Rev Bras Ginecol Obstet 2020; 42(06): 356-364
DOI: 10.1055/s-0040-1712125
Review Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Progress in Local Treatment of Breast Cancer: A Narrative Review

Evolução do tratamento local do câncer de mama: revisão narrativa
Francisco Pimentel Cavalcante 
1   Breast Surgery Service, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil
,
Eduardo Camargo Millen 
2   Breast Surgery Service, Clínica São Vicente, Rio de Janeiro, RJ, Brazil
,
Felipe Pereira Zerwes 
3   School of Medicine, Breast Surgery Service, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Guilherme Garcia Novita 
4   Breast Surgery Service, Grupo Américas, São Paulo, SP, Brazil
› Institutsangaben
Weitere Informationen

Publikationsverlauf

29. Oktober 2019

16. März 2020

Publikationsdatum:
30. Juni 2020 (online)

   Lizenzen und Reprints

Abstract

The present paper reports on the local treatment of breast cancer from a historical perspective. A search for articles written in English was made in the Medline and EMBASE databases, and 40 papers were selected. Over the past 10 years, various randomized, controlled clinical trials on the local treatment of breast cancer indicated that patients with the same molecular subtype may receive different individualized surgical treatments aimed at optimizing systemic adjuvant therapy. With a view to retaining the gains made in disease-free and overall survival, surgical techniques have advanced from radical surgery to conservative mastectomies, thus reducing sequelae, while adjuvant and neoadjuvant therapies have contributed toward controlling the disease, both distant metastases and local recurrence. Current studies evaluate whether future breast cancer therapy may even succeed in eliminating surgery to the breast and axilla altogether.

Resumo

Este artigo discute o tratamento local do câncer de mama a partir de uma perspectiva histórica. Uma busca de artigos publicados em inglês foi realizada nas bases de dados Medline e EMBASE, sendo selecionados 40 artigos. Nos últimos 10 anos, vários ensaios clínicos controlados e randomizados sobre o tratamento local do câncer de mama indicaram que pacientes com o mesmo subtipo molecular podem receber diferentes tratamentos cirúrgicos individualizados com o objetivo de otimizar a terapia adjuvante sistêmica. Pretendendo reter os ganhos obtidos na sobrevida livre de doença e na sobrevida global, as técnicas cirúrgicas avançaram progressivamente da cirurgia radical para mastectomias conservadoras, reduzindo sequelas, enquanto as terapias adjuvantes e neoadjuvantes contribuíram para o controle da doença, tanto em relação às metástases distantes quanto à recorrência local. Estudos atuais avaliam se a terapia futura contra o câncer de mama poderá até mesmo eliminar a cirurgia da mama e da axila por completo.

Keywords

breast cancer therapy - breast-conserving therapy - sentinel node biopsy - mastectomy - neoadjuvant and adjuvant therapy

Palavras-chave

terapia de câncer de mama - terapia de conservação da mama - biópsia de linfonodo sentinela - mastectomia - terapia neoadjuvante e adjuvante
 

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