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CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2018; 54(03): 147-152
DOI: 10.1055/s-0040-1712840
Original Article

Oxidative Stress is Independent Factor for End-stage Renal Disease in Type 2 Diabetes Mellitus Patients

Authors

  • Kirti Balyan‡

    Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi

  • Pragya Sharma‡

    Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi

  • Kailash Chandra

    Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi

  • Sarita Agarwal

    Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi

  • S.K. Jain

    Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi

Funding This work was supported by intramural funding from Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi.
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ABSTRACT

An imbalance between oxidant and antioxidants is thought to precede the development of renal lesions. The aim of present study is to determine the relationship between oxidative markers and severity of microalbuminuria in patients with type 2 diabetes mellitus (T2DM). A total of 100 T2DM patients (50 males and 50 females) participated in this study. They were screened for microalbuminuria along with oxidative status in patients. Microalbuminuria was detected by measuring the albumin to creatinine ratio (ACR) in urine samples. Patients were divided into two groups; normoalbuminuria (n=36) and microalbuminuria (n=64) as per the ACR levels. No difference in the groups was observed in terms of age, sex, glycated hemoglobin (HbA1c) and blood pressure. The level of oxidative stress was significantly higher in microalbuminuria group of T2DM patients. A significant correlation was observed between ACR and lipid peroxidation (MDA) levels. We conclude that oxidative stress is one of the important mediators of end-stage renal disease (ESRD).

Keywords

Type 2 diabetes mellitus - microalbuminuria - diabetic nephropathy - albumin to creatinine ratio - oxidative stress


Publication History

Article published online:
09 May 2020

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