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CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2018; 54(03): 153-159
DOI: 10.1055/s-0040-1712841
Original Article

Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

Bushra Parveen
School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi
,
Manjari Tripathi
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi
,
Divya Vohora
School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi
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ABSTRACT

Background: Antiepileptic drug (AED) therapy has been claimed to deteriorate bone health. Majority of the research was inclined towards vitamin-D deficiency as the patho-mechanism. However, after the role of Wnt in bone metabolism was discovered, it has paved way for investigating the role of Wnt inhibitors in mediating effects on bone accrual. Recently, we have reported the modulation of two Wnt inhibitors, sclerostin and dickkopf-1 (DKK-1), following AED therapy in Indian women with epilepsy, however, the subgroup analysis for individual drug is elucidated in this report.

Methods: Individual analysis for our earlier cross-sectional study on three AEDs, carbamazepine (CBZ), sodium valproate (SVP) and levetiracetam (LTM), on sclerostin and dickkopf-1, and their correlation with receptor activator of nuclear factor kappaB ligand (RANKL) and serum 25-hydroxy vitamin D (25OHD) was assessed in Indian women with epilepsy.

Results: We observed enhanced sclerostin and 25OHD levels with all three AEDs while serum RANKL was higher with SVP and LTM only. Further, serum DKK-1 levels were lowered with CBZ and LTM. Sclerostin showed a positive correlation with RANKL in CBZ group, while DKK-1 presented no such relationship.

Conclusion: As sclerostin is more specific than DKK-1, we may conclude that these drugs may compromise bone health through disturbance in Wnt signaling mechanisms.

Keywords

sclerostin - DKK-1 - RANKL - 25OHD - sodium valproate - carbamazepine - levetiracetam


Publikationsverlauf

Artikel online veröffentlicht:
09. Mai 2020

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