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CC BY 4.0 · Glob Med Genet 2020; 07(01): 003-007
DOI: 10.1055/s-0040-1713610
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Cancer Treatment: An Epigenetic View

Cansu Aydin
2   Department of Molecular Biology and Genetics, Faculty of Medicine, Trakya University, Merkez/Edirne, Turkey
,
Rasime Kalkan
1   Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Turkish Republic of Northern Cyprus
› Author Affiliations
Further Information

Publication History

Publication Date:
15 July 2020 (online)

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Abstract

Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of epigenetic therapeutics.

Keywords

cancer - treatment - epigenetics - epidrugs - methylation
 

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