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Semin Liver Dis 2020; 40(04): 392-402
DOI: 10.1055/s-0040-1713657
Review Article

Simplification of Care for Chronic Hepatitis C Virus Infection

Jean-Michel Pawlotsky
1   Department of Virology, National Reference Center for Viral Hepatitis B, C and D, Henri Mondor Hospital, University of Paris-Est—INSERM U955, Créteil, France
,
Christian B. Ramers
2   Division of Infectious Diseases, Department of Medicine, UC San Diego School of Medicine, La Jolla, California
,
John F. Dillon
3   Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom
,
Jordan J. Feld
4   Toronto Centre for Liver Disease, University Health Network, Sandra Rotman Centre for Global Health, Toronto, ON, Canada
,
Jeffrey V. Lazarus
5   Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain
› Author Affiliations Funding This study was funded by AbbVie.
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Abstract

In 2016, the World Health Organization (WHO) set a target for eliminating viral hepatitis as a major public health threat by 2030. However, while today's highly effective and well-tolerated pangenotypic direct-acting antiviral regimens have maximized simplification of hepatitis C virus (HCV) treatment, there remain a plethora of barriers to HCV screening, diagnosis, and linkage to care. As of 2017, only 19% of the estimated 71 million individuals living with chronic HCV worldwide were diagnosed and in 2015 to 2016, only 21% of diagnosed individuals had accessed treatment. Simplification and decentralization of the HCV care cascade would bolster patient engagement and support the considerable scale-up needed to achieve WHO targets. Recent developments in HCV screening and diagnosis, together with reduced pretreatment assessment and on-treatment monitoring requirements, can further streamline the care continuum, ensuring patients are linked to care quickly and earlier in the disease course, and minimize clinic visits.

Keywords

hepatitis C virus - care cascade - screening - diagnosis - treatment


Publication History

Article published online:
28 July 2020

© 2020. Thieme. All rights reserved.

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