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CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2020; 11(04): 293-294
DOI: 10.1055/s-0040-1713710
Case Report

Posttransplant Lymphoproliferative Disorder Involving the Gastrointestinal Tract

Tejas Kirtane
1   Department of Gastroenterology Hepatology and Nutrition, University of Texas Health Science Center, Texas, United States
,
Guneesh S. Uberoi
1   Department of Gastroenterology Hepatology and Nutrition, University of Texas Health Science Center, Texas, United States
,
Angad S. Uberoi
1   Department of Gastroenterology Hepatology and Nutrition, University of Texas Health Science Center, Texas, United States
,
Sanam Loghavi
2   Department of Hematopathology, University of Texas MD Anderson Cancer Center, Texas, United States
,
L. Jeffrey Medeiros
2   Department of Hematopathology, University of Texas MD Anderson Cancer Center, Texas, United States
,
Manoop S. Bhutani
1   Department of Gastroenterology Hepatology and Nutrition, University of Texas Health Science Center, Texas, United States
› Author Affiliations Financial Support and Sponsorship None.
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Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a rare and life-threatening complication of both solid organ transplantation and hematopoietic stem cell transplantation. In most cases, PTLD develops in Epstein–Barr virus (EBV)-seropositive individuals in the setting of chronic immunosuppression and decreased T-cell surveillance. Clinical manifestations of PTLD may be nonspecific, resembling primary EBV infection (fever, night sweats, malaise, and cervical lymphadenopathy), or it can involve the central nervous system, bone marrow, kidneys, liver, lungs, and gastrointestinal tract. Gastrointestinal symptoms in the posttransplant setting may indicate underlying PTLD, and it is important for physicians to be able to recognize its appearance on endoscopy.

Keywords

Epstein–Bar virus - hematopoietic stem-cell transplantation - posttransplant lymphoproliferative disorder - solid-organ transplantation


Publication History

Article published online:
21 December 2020

© 2020. Society of Gastrointestinal Endoscopy of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Gottschalk S, Rooney CM, Heslop HE. Post-transplant lymphoproliferative disorders. Annu Rev Med 2005; 56: 29-44
    CrossrefPubMedSearch in Google Scholar
  • 2 Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343 (07) 481-492
    CrossrefPubMedSearch in Google Scholar
  • 3 Caillard S, Lamy FX, Quelen C. et al. French Transplant Centers. Epidemiology of posttransplant lymphoproliferative disorders in adult kidney and kidney pancreas recipients: report of the French registry and analysis of subgroups of lymphomas. Am J Transplant 2012; 12 (03) 682-693
    CrossrefPubMedSearch in Google Scholar
  • 4 Green M, Michaels MG. Epstein-Barr virus infection and posttransplant lymphoproliferative disorder. Am J Transplant 2013; 13 (Suppl. 03) 41-54, quiz 54
    CrossrefPubMedSearch in Google Scholar
  • 5 Petrara MR, Giunco S, Serraino D, Dolcetti R, De Rossi A. Post-transplant lymphoproliferative disorders: from epidemiology to pathogenesis-driven treatment. Cancer Lett 2015; 369 (01) 37-44
    CrossrefPubMedSearch in Google Scholar