Abstract
Posttransplant lymphoproliferative disorder (PTLD) is a rare and life-threatening
complication of both solid organ transplantation and hematopoietic stem cell transplantation.
In most cases, PTLD develops in Epstein–Barr virus (EBV)-seropositive individuals
in the setting of chronic immunosuppression and decreased T-cell surveillance. Clinical
manifestations of PTLD may be nonspecific, resembling primary EBV infection (fever,
night sweats, malaise, and cervical lymphadenopathy), or it can involve the central
nervous system, bone marrow, kidneys, liver, lungs, and gastrointestinal tract. Gastrointestinal
symptoms in the posttransplant setting may indicate underlying PTLD, and it is important
for physicians to be able to recognize its appearance on endoscopy.
Keywords
Epstein–Bar virus - hematopoietic stem-cell transplantation - posttransplant lymphoproliferative
disorder - solid-organ transplantation
