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CC BY 4.0 · Rev Bras Ginecol Obstet 2020; 42(12): 829-833
DOI: 10.1055/s-0040-1714133
Review Article

Reproductive Outcomes in Cases of Subclinical Hypothyroidism and Thyroid Autoimmunity: A Narrative Review

Resultados reprodutivos nos casos de hipotireoidismo subclínico e autoimunidade tireoidiana: Uma revisão narrativa
Bruno Ramalho de Carvalho 
1   Hospital Sírio-Libanês, Brasília, Distrito Federal, Brazil
,
Andrea Prestes Nácul 
2   Human Reproduction Unit, Hospital Fêmina, Grupo Hospitalar Conceição, Porto Alegre, Rio Grande do Sul, Brazil
,
Cristina Laguna Benetti-Pinto 
3   Department of Obstetrics and Gynecology, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil
,
Ana Carolina Japur de Sá Rosa-e-Silva 
4   Departamento of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
,
José Maria Soares Júnior 
5   Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil
,
Gustavo Arantes Rosa Maciel 
5   Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil
,
Edmund Chada Baracat 
5   Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil
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Abstract

Thyroid diseases are relatively common in women in the reproductive period. It is currently understood that clinically-evident thyroid disorders may impair ovulation and, consequently, fertility. However, to date it has not been proven that high serum levels of thyroid-stimulating hormone and/or positivity for antithyroid antibodies are associated to a reduction in fertility, mainly in the absence of altered thyroxine levels. The present comprehensive review aims to present current data on the association between subclinical hypothyroidism and/or thyroid autoimmunity and reproductive outcomes.

Resumo

As doenças da tireoide são relativamente comuns em mulheres no período reprodutivo. Atualmente, entende-se que distúrbios da tireoide clinicamente evidentes podem prejudicar a ovulação e, consequentemente, a fertilidade. No entanto, não se provou até o presente que níveis séricos altos do hormônio estimulador da tireoide e/ou positividade para anticorpos antitireoidianos estão associados a uma redução na fertilidade, sobretudo na ausência de níveis alterados de tiroxina. Esta revisão narrativa tem como objetivo apresentar dados atuais sobre a associação entre hipotireoidismo subclínico e/ou autoimunidade tireoidiana e resultados reprodutivos.

Keywords

thyroid diseases - thyroid function tests - thyroid hormones - hypothyroidism - autoimmunity - female infertility

Palavras-chave

doenças da tireoide - testes de função da tireoide - hormônios da tireoide - hipotireoidismo - autoimunidade - infertilidade feminina


Publikationsverlauf

Eingereicht: 19. Mai 2020

Angenommen: 03. Juni 2020

Artikel online veröffentlicht:
21. Dezember 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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