Reproductive Outcomes in Cases of Subclinical Hypothyroidism and Thyroid Autoimmunity: A Narrative Review

Bruno Ramalho de Carvalho; Andrea Prestes Nácul; Cristina Laguna Benetti-Pinto; Ana Carolina Japur de Sá Rosa-e-Silva; José Maria Soares Júnior; Gustavo Arantes Rosa Maciel; Edmund Chada Baracat

doi:10.1055/s-0040-1714133

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, Table of Contents

CC BY 4.0 · Rev Bras Ginecol Obstet 2020; 42(12): 829-833
DOI: 10.1055/s-0040-1714133

Review Article

Reproductive Outcomes in Cases of Subclinical Hypothyroidism and Thyroid Autoimmunity: A Narrative Review

Resultados reprodutivos nos casos de hipotireoidismo subclínico e autoimunidade tireoidiana: Uma revisão narrativa

Bruno Ramalho de Carvalho

¹Hospital Sírio-Libanês, Brasília, Distrito Federal, Brazil

,

Andrea Prestes Nácul

²Human Reproduction Unit, Hospital Fêmina, Grupo Hospitalar Conceição, Porto Alegre, Rio Grande do Sul, Brazil

,

Cristina Laguna Benetti-Pinto

³Department of Obstetrics and Gynecology, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

,

Ana Carolina Japur de Sá Rosa-e-Silva

⁴Departamento of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

,

José Maria Soares Júnior

⁵Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil

,

Gustavo Arantes Rosa Maciel

⁵Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil

,

Edmund Chada Baracat

⁵Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil

› Author Affiliations

Abstract

Thyroid diseases are relatively common in women in the reproductive period. It is currently understood that clinically-evident thyroid disorders may impair ovulation and, consequently, fertility. However, to date it has not been proven that high serum levels of thyroid-stimulating hormone and/or positivity for antithyroid antibodies are associated to a reduction in fertility, mainly in the absence of altered thyroxine levels. The present comprehensive review aims to present current data on the association between subclinical hypothyroidism and/or thyroid autoimmunity and reproductive outcomes.

Resumo

As doenças da tireoide são relativamente comuns em mulheres no período reprodutivo. Atualmente, entende-se que distúrbios da tireoide clinicamente evidentes podem prejudicar a ovulação e, consequentemente, a fertilidade. No entanto, não se provou até o presente que níveis séricos altos do hormônio estimulador da tireoide e/ou positividade para anticorpos antitireoidianos estão associados a uma redução na fertilidade, sobretudo na ausência de níveis alterados de tiroxina. Esta revisão narrativa tem como objetivo apresentar dados atuais sobre a associação entre hipotireoidismo subclínico e/ou autoimunidade tireoidiana e resultados reprodutivos.

Keywords

thyroid diseases - thyroid function tests - thyroid hormones - hypothyroidism - autoimmunity - female infertility

Palavras-chave

doenças da tireoide - testes de função da tireoide - hormônios da tireoide - hipotireoidismo - autoimunidade - infertilidade feminina

Full Text

References

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