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CC BY-NC-ND 4.0 · Eur J Dent 2020; 14(04): 544-550
DOI: 10.1055/s-0040-1715788
Original Article

Role of Lymphocytes CD4/CD8 Ratio and Immunoglobulin G Cytomegalovirus as Potential Markers for Systemic Lupus Erythematosus Patients with Periodontal Disease

Kusworini Handono
1   Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
,
Nanda Rachmad Putra Gofur
2   Biomedical Science, Postgraduate Program, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
,
Nurdiana Nurdiana
3   Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
,
Handono Kalim
4   Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
,
Cesarius Singgih Wahono
4   Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
,
Sri Poeranto
5   Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
,
Wisnu Barlianto
6   Department of Pediatric, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
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Abstract

Objectives The aim of the study was to analyze the correlation between periodontitis severity in systemic lupus erythematosus (SLE) with CD4/CD8 lymphocytes ratio and cytomegalovirus gamma immunoglobulin (IgG CMV) level.

Materials and Methods This is a descriptive study using a cross-sectional approach that included 93 subjects who were diagnosed with SLE in Rheumatology Department, Saiful Anwar Hospital, during 2017 to 2019. Periodontitis severity was assessed by periodontal Index (PI). CD4/CD8 lymphocyte ratio was determined using flow cytometry and IgG CMV levels using enzyme-linked immunosorbent assay.

Statistical Analysis The differences among the three groups were analyzed using analysis of variance. Correlation among the groups was calculated using Spearman/Pearson correlation coefficient test, while regression analysis was done using Statistical Package for the Social Sciences.

Results The mean of periodontitis severity and standard deviation in SLE was 2.66 ± 1.02. There were negative correlation between CD4/CD8 lymphocyte ratio with periodontal index (r = –0.971) and positive correlation between IgG CMV level with periodontal index (r = 0.977).

Conclusions Inverted CD4/CD8 ratio and IgG CMV were found associated with periodontitis severity in SLE patient. Further research was recomended that CD4/CD8 lymphocytes ratio and IgG CMV can be used as a potensial marker of periodontitis severity in SLE patients.

Keywords

periodontitis - systemic lupus erythematous - CD4/CD8 ratio - IgG CMV


Publikationsverlauf

Artikel online veröffentlicht:
15. September 2020

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Thieme Medical and Scientific Publishers Private Ltd.
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