Detection and Characterization of Musculoskeletal Cancer Using Whole-Body Magnetic Resonance Imaging

Amanda Isaac; Frederic Lecouvet; Danoob Dalili; Laura Fayad; Vasiliki Pasoglou; Olympia Papakonstantinou; Shivani Ahlawat; Christina Messiou; Marc-André Weber; Anwar R. Padhani

doi:10.1055/s-0040-1719018

Seminars in Musculoskeletal Radiology, Table of Contents

Semin Musculoskelet Radiol 2020; 24(06): 726-750
DOI: 10.1055/s-0040-1719018

Review Article

Detection and Characterization of Musculoskeletal Cancer Using Whole-Body Magnetic Resonance Imaging

Amanda Isaac

¹School of Biomedical Engineering & Imaging Sciences, Kings College London, United Kingdom

²Guy's & St Thomas' Hospitals, London, United Kingdom

,

Frederic Lecouvet

³Department of Radiology, Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCLouvain), Brussels, Belgium

,

Danoob Dalili

¹School of Biomedical Engineering & Imaging Sciences, Kings College London, United Kingdom

⁴Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

,

Laura Fayad

⁵The Russell H. Morgan Department of Radiology and Radiological Science, John's Hopkins School of Medicine, Baltimore, Maryland

,

Vasiliki Pasoglou

³Department of Radiology, Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCLouvain), Brussels, Belgium

,

Olympia Papakonstantinou

⁶2nd Department of Radiology, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece

,

Shivani Ahlawat

⁵The Russell H. Morgan Department of Radiology and Radiological Science, John's Hopkins School of Medicine, Baltimore, Maryland

,

Christina Messiou

⁷The Royal Marsden Hospital, London, United Kingdom

⁸The Institute of Cancer Research, London, United Kingdom

,

Marc-André Weber

⁹Institute of Diagnostic and Interventional Radiology, Paediatric Radiology and Neuroradiology, University Medical Centre Rostock, Rostock, Germany

,

Anwar R. Padhani

⁸The Institute of Cancer Research, London, United Kingdom

¹⁰Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom

› Author Affiliations

Abstract

Whole-body magnetic resonance imaging (WB-MRI) is gradually being integrated into clinical pathways for the detection, characterization, and staging of malignant tumors including those arising in the musculoskeletal (MSK) system. Although further developments and research are needed, it is now recognized that WB-MRI enables reliable, sensitive, and specific detection and quantification of disease burden, with clinical applications for a variety of disease types and a particular application for skeletal involvement. Advances in imaging techniques now allow the reliable incorporation of WB-MRI into clinical pathways, and guidelines recommending its use are emerging. This review assesses the benefits, clinical applications, limitations, and future capabilities of WB-MRI in the context of other next-generation imaging modalities, as a qualitative and quantitative tool for the detection and characterization of skeletal and soft tissue MSK malignancies.

Keywords

whole-body MRI - precision oncology - bone metastasis - myeloma - next-generation imaging

Full Text

References

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