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Synlett 2021; 32(17): 1730-1734
DOI: 10.1055/s-0040-1719828
DOI: 10.1055/s-0040-1719828
letter
PEG-Supported Hypervalent Iodine Reagent for Sulfonamide Synthesis
Abstract
A reusable and recoverable PEG-supported hypervalent iodine reagent is reported. This hypervalent iodine reagent, immobilized in a soluble polymer support, was easily prepared in six steps from PEG-OH 2000. This reagent was successfully applied in a mild sulfonamide synthesis using a sulfinate salt and an amine in up to 95% yield. The use of the soluble polymer allowed a facile workup procedure and reaction monitoring, by simple precipitation and filtration of the reagent, with an easy recovery and subsequent re-oxidation and reuse. This approach greatly improves the sustainability of this sulfonamide synthesis method, avoiding frequent preparation of reagents and generation of waste during the purification steps.
Key words
PEG - hypervalent iodine - sulfonamide synthesis - sustainable synthesis - soluble polymer supportSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1719828.
- Supporting Information
Publication History
Received: 16 July 2021
Accepted after revision: 06 August 2021
Article published online:
23 August 2021
© 2021. Thieme. All rights reserved
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