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Synthesis 2022; 54(20): 4401-4425
DOI: 10.1055/s-0040-1719884
DOI: 10.1055/s-0040-1719884
review
Biocatalytic One-Carbon Transfer – A Review
Philipp Germer
,
Jennifer N. Andexer
,
Michael Müller∗
In memory of Dr. Arren Bar-Even
Abstract
This review provides an overview of different C1 building blocks as substrates of enzymes, or part of their cofactors, and the resulting functionalized products. There is an emphasis on the broad range of possibilities of biocatalytic one-carbon extensions with C1 sources of different oxidation states. The identification of uncommon biosynthetic strategies, many of which might serve as templates for synthetic or biotechnological applications, towards one-carbon extensions is supported by recent genomic and metabolomic progress and hence we refer principally to literature spanning from 2014 to 2020.
1 Introduction
2 Methane, Methanol, and Methylamine
3 Glycine
4 Nitromethane
5 SAM and SAM Ylide
6 Other C1 Building Blocks
7 Formaldehyde and Glyoxylate as Formaldehyde Equivalents
8 Cyanide
9 Formic Acid
10 Formyl-CoA and Oxalyl-CoA
11 Carbon Monoxide
12 Carbon Dioxide
13 Conclusions
Publikationsverlauf
Eingereicht: 11. September 2021
Angenommen nach Revision: 09. Dezember 2021
Artikel online veröffentlicht:
08. August 2022
© 2022. Thieme. All rights reserved
Georg Thieme Verlag KG
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