CC BY 4.0 · SynOpen 2023; 07(02): 277-289
DOI: 10.1055/s-0040-1720072
review
Virtual Collection Click Chemistry and Drug Discovery

Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications

Smritilekha Bera
,
Dhananjoy Mondal


Abstract

This short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects glycosaminoglycans with other labelled or attached functionalities. The synthesized glycosaminoglycan (GAG) conjugates act as drug carriers, forming hydrogels or nanohydrogels for localized drug delivery or injectable GAGs and so on. These are used in research on antithrombotic agents, protein binding, and hepatocyte growth factors, as well as in mechanistic studies of glycosaminoglycans biosynthesis and wound healing.

1 Introduction

2 Synthetic Modification of GAGS

3 Click Chemistry

4 Modification of GAGS Applying Click Chemistry

5 Conclusions

6 Abbreviations



Publication History

Received: 03 March 2023

Accepted after revision: 08 May 2023

Article published online:
19 June 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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