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Synthesis 2022; 54(05): 1309-1320
DOI: 10.1055/s-0040-1720890
DOI: 10.1055/s-0040-1720890
paper
Facile Synthesis of Spirocyclic Tetrahydroquinolines via C(sp3)–H Functionalization in a Cascade Redox Process
We are grateful to the Taishan Scholar Project of Shandong Province (tsqn201909131, ts201511033), NSFC (21878167), and The Key Research Foundation of Science of Shandong Province (ZR2020KB007). Project support by the Natural Science Foundation of Shandong Province (ZR2020QB047) and the Key Research and Development Program of Qingdao Technical College (2020ZDYF06) are also gratefully acknowledged.
Abstract
An environmentally benign cascade redox process was developed for the efficient construction of the pharmaceutically significant spirocyclic tetrahydroquinolines via sequential SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization. This green transformation has the features of being catalyst-free, additive-free, operationally simple, and has high step- and atom-economy.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1720890.
- Supporting Information
Publikationsverlauf
Eingereicht: 28. Juli 2021
Angenommen nach Revision: 30. August 2021
Artikel online veröffentlicht:
25. Oktober 2021
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