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CC BY 4.0 · Rev Bras Ginecol Obstet 2021; 43(01): 066-071
DOI: 10.1055/s-0040-1721351
Case Report

Does Big Mean Evil? Giant, but Benign Uterine Leiomyoma: Case Report and Review of the Literature

Será que grande significa maligno? Leiomioma gigante, porém benigno: Relato de caso e revisão de literatura
Luiz Gustavo Oliveira Brito 
1   Department of Obstetrics and Gynecology, Faculdade de Ciências Médicas da Universidade de Campinas, Campinas, SP, Brazil
2   Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil
,
Natalia Lysei Ueno 
2   Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil
,
Maira Rossmann Machado 
1   Department of Obstetrics and Gynecology, Faculdade de Ciências Médicas da Universidade de Campinas, Campinas, SP, Brazil
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Abstract

Uterine leiomyoma is the most prevalent benign type of gynecological tumor. It affects more than 80% of women worldwide and, within this group, more than 50% may be asymptomatic. However, large fibroid volumes may be associated with symptoms of extrinsic compression, and most of the cases do not present atypical cells. We present the case of a 49-year-old woman who underwent a total abdominal hysterectomy of a 13.5-kg uterine leiomyoma with no malignancies at histopathology and review the literature about giant uterine leiomyomas and their clinical repercussion. We concluded that large volumes do not always pose a threat regarding malignancy; however, future molecular studies are needed to investigate giant uterine fibroids.

Resumo

Leiomioma uterino é o tumor benigno ginecológico de maior prevalência. Ele afeta mais de 80% das mulheres no mundo e, deste grupo, mais de 50% podem ser assintomáticas. Contudo, miomas de grande volume podem ser associados com sintomas de compressão extrínseca, e a maioria dos casos não apresentam células atípicas. Nós apresentamos o caso de uma mulher de 49 anos que foi submetida a histerectomia total abdominal de um espécime de 13,5 quilos sem malignidades ao exame histopatológico. Também revisamos a literatura sobre leiomiomas uterinos de grande volume e sua repercussão clínica. Concluímos que grandes volumes nem sempre representam um risco relacionado à malignidade; contudo, estudos moleculares futuros são necessários para investigar leiomiomas uterinos gigantes.

Keywords

uterine leiomyoma - giant tumors - gynecological tumors

Palavras-chave

leiomioma - neoplasias ginecológicas - tumores ginecológicos


Publication History

Received: 25 May 2020

Accepted: 22 September 2020

Article published online:
29 January 2021

© 2021. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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