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CC BY-NC-ND 4.0 · Revista Urología Colombiana / Colombian Urology Journal 2020; 29(04): 235-239
DOI: 10.1055/s-0040-1721357
Original Article | Artículo Original
Oncological Urology/Urología Oncológica

Factores asociados a la histología de masa residual retroperitoneal post quimioterapia en tumor testicular de células germinales

Factors Associated with the Histology of Retroperitoneal Residual Mass Post Chemotherapy in Testicular Germ Cell Tumor
Lynda Torres 
1   Médica Uróloga. Pontificia Universidad Javeriana, Bogotá, Colombia
,
Jose Gustavo Ramos
2   Médico Urólogo, Urología Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia
,
Rodolfo Varela
2   Médico Urólogo, Urología Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia
,
Fabian Godoy
2   Médico Urólogo, Urología Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia
,
Paola Andrea Orrego
3   Médica residente, Universidad Militar Nueva Granada, Bogotá, Colombia
,
AysaVanessa Mosquera
3   Médica residente, Universidad Militar Nueva Granada, Bogotá, Colombia
,
Sandra Viviana Pulido Vecino
3   Médica residente, Universidad Militar Nueva Granada, Bogotá, Colombia
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Resumen

Objetivo El objetivo de este estudio es describir las características y factores relacionados con la histología de la masa residual postquimioterapia en pacientes con tumor de células germinales de origen testicular sometidos a linfadenectomía retroperitoneal durante 12 años de seguimiento.

Métodos Retrospectivamente se recolectaron datos clínicos, quirúrgicos y patológicos de la historia clínica de los pacientes en un centro de referencia de manejo de cáncer durante un periodo de 12 años. Se estimó la asociación entre los datos recolectados con la histología del tumor residual post quimioterapia.

Resultados Se incluyeron 64 pacientes, la edad promedio fue 28.1 años, el tamaño promedio de masa residual fue de 6.7 cm. La histología de la masa residual fue teratoma en 60.9%, necrosis 26.5% y tumor viable 12.5%. El grupo pronóstico tiene asociación con la histología de la masa retroperitoneal. Las masas con histología de necrosis tuvieron menor tamaño con media 6.5 cm mientras que otras histologías tuvieron tamaño promedio de la masa residual de 10.4 cm.

Conclusiones La LNDRP-PC es el estándar de tratamiento en masas residuales retroperitoneales después de quimioterapia y puede generar sobre-tratamiento hasta en 50% de los casos. El teratoma en la histología testicular está relacionado mayor tamaño de la masa residual retroperitoneal. Las características histológicas de la masa residual son comparables con otras series.

Abstract

Objective The aim of the study is to describe factors and characteristics related with the post-chemotherapy residual mass histology in patients who undergoing RPLND.

Methods Clinical, surgical and pathological data were retrospectively recorded from medical records of patients with diagnosis of germ cell tumor and post-chemotherapy residual retroperitoneal tumor in a cancer referral center over a period of 12 years. The association between the data collected and the post-chemotherapy residual tumor histology was assessed.

Results Sixty-four patients were included with average age of 28.1 years. The mean residual mass size was 6.7 cm. The histology of the mass was teratoma in 60.9%, necrosis 26.5% and viable tumor 12.5%. Prognostic group was associated with the mass histology. Mass with necrosis histology was smaller with mean size of 6.5 cm, while other histologies had an average mass size of 10.4 cm.

Conclusion PC-RPLND is the standard of management of retroperitoneal residual mass after chemotherapy and could over treat in up to 50% of cases. Teratoma component in testicular histology is related to increase size of the residual mass. Histology findings of the retroperitoneal mass are comparable with other series.

Palabras Clave

neoplasias testiculares - disección de ganglios linfáticos retroperitoneales - necrosis - teratoma

Keywords

testicular neoplasms - retroperitoneal lymph node dissection - necrosis - teratoma


Publication History

Received: 31 May 2020

Accepted: 14 September 2020

Article published online:
16 December 2020

© 2020. Sociedad Colombiana de Urología. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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